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Purpose <p>Time-resolved spectroscopy (TRS) has recently become clinically available and offers superior measurement accuracy over conventional spatially resolved spectroscopy (SRS). This study evaluated the feasibility of transitioning from the SRS-based INVOS 5100C to the TRS-based tNIRS-1 by comparing cerebral oxygen saturation measurements taken during pediatric cardiac surgery.</p> Methods <p>We retrospectively analyzed data from 149 children (&lt; 6&#xa0;years) who had undergone cardiac surgery. We compared simultaneously measured cerebral tissue oxygen saturation (StO₂) (tNIRS-1) and regional cerebral oxygen saturation (rSO₂) (INVOS 5100C) after anesthesia induction. Both values were assessed against reference cerebral oxygen saturation (REF CX). Clinical decisions based on StO₂ and rSO₂ were also compared to current reference thresholds.</p> Results <p>The Wilcoxon matched-pairs signed-rank test showed significantly lower StO₂ than rSO₂ (54.8 [48.9–61.0] vs. 69 [61–75], <i>p</i> &lt; 0.0001); this observation was consistent across all age groups and cyanotic statuses. Bland–Altman analysis confirmed non-interchangeability (mean bias: −&#xa0;13.1; limits: −&#xa0;31.7 to 5.5). Compared with REF CX, rSO₂ more closely reflected true cerebral oxygenation (mean bias: −&#xa0;5.7; limits: −&#xa0;22.5 to 11.2) than StO₂ (mean bias: −&#xa0;19.3; limits: −&#xa0;36.5 to −&#xa0;2.1). Most patients were classified as normal by rSO₂ but borderline by StO₂.</p> Conclusion <p>A transition from INVOS 5100C to tNIRS-1 is not currently feasible due to clinically significant discrepancies. Therefore, it may be appropriate to either select the device based on the specific measurement objectives or use both devices in a complementary manner.</p>

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Comparison of cerebral oxygen saturation values determined by time-resolved spectroscopy and spatially resolved spectroscopy in pediatric patients with congenital heart disease

  • 期刊论文

  • 发表日期：

    2025年7月11日

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  • Tomohiko Suemori,
  • Takashi Yamada,
  • Tatsuya Nagano,
  • Masaaki Satoh,
  • Mamoru Takeuchi

摘要

Purpose

Time-resolved spectroscopy (TRS) has recently become clinically available and offers superior measurement accuracy over conventional spatially resolved spectroscopy (SRS). This study evaluated the feasibility of transitioning from the SRS-based INVOS 5100C to the TRS-based tNIRS-1 by comparing cerebral oxygen saturation measurements taken during pediatric cardiac surgery.

Methods

We retrospectively analyzed data from 149 children (< 6 years) who had undergone cardiac surgery. We compared simultaneously measured cerebral tissue oxygen saturation (StO₂) (tNIRS-1) and regional cerebral oxygen saturation (rSO₂) (INVOS 5100C) after anesthesia induction. Both values were assessed against reference cerebral oxygen saturation (REF CX). Clinical decisions based on StO₂ and rSO₂ were also compared to current reference thresholds.

Results

The Wilcoxon matched-pairs signed-rank test showed significantly lower StO₂ than rSO₂ (54.8 [48.9–61.0] vs. 69 [61–75], p < 0.0001); this observation was consistent across all age groups and cyanotic statuses. Bland–Altman analysis confirmed non-interchangeability (mean bias: − 13.1; limits: − 31.7 to 5.5). Compared with REF CX, rSO₂ more closely reflected true cerebral oxygenation (mean bias: − 5.7; limits: − 22.5 to 11.2) than StO₂ (mean bias: − 19.3; limits: − 36.5 to − 2.1). Most patients were classified as normal by rSO₂ but borderline by StO₂.

Conclusion

A transition from INVOS 5100C to tNIRS-1 is not currently feasible due to clinically significant discrepancies. Therefore, it may be appropriate to either select the device based on the specific measurement objectives or use both devices in a complementary manner.