Scholarlink

Background <p>Sphincter of Oddi dysfunction (SOD) can cause unexplained biliary pain and idiopathic pancreatitis. Although Rome IV criteria recommend sphincter of Oddi manometry (SOM) for diagnosis, SOM is invasive and carries pancreatitis risk. We hypothesized that cine-dynamic magnetic resonance cholangiopancreatography (MRCP) could non-invasively visualize bile and pancreatic juice flow, enabling functional papillary assessment.</p> Methods <p>In this prospective observational study, 40 participants were enrolled, and 29 were included in the final analysis after excluding 11 participants who did not meet the Rome IV criteria (10 healthy controls, 7 with suspected biliary-type SOD [BSOD], and 12 with suspected pancreatic-type SOD [PSOD]). Cine-dynamic MRCP was performed with 20 sequential frames over 5&#xa0;min. Two quantitative indices were assessed: flow frequency and secretion grade (distance traveled by bile or pancreatic juice).</p> Results <p>Bile flow frequency and secretion grade were significantly lower in both BSOD and PSOD than in controls: frequency (median [range], 13.5 [6–19] in controls vs. 2.0 [1–17] in BSOD, <i>p</i> = 0.006; vs. 8.0 [3–14] in PSOD, <i>p</i> = 0.008) and secretion grade (1.6 [0.3–2.05] in controls vs. 0.2 [0.1–1.3] in BSOD, <i>p</i> = 0.001; vs. 0.5 [0.15–1.75] in PSOD, <i>p</i> = 0.03). Pancreatic juice flow showed no significant difference between BSOD and controls but was significantly reduced in PSOD: frequency (16 [14–19] in controls vs. 9.5 [4–17] in PSOD, <i>p</i> &lt; 0.001) and secretion grade (2.15 [0.7–3.25] in controls vs. 0.98 [0.25–2.9] in PSOD, <i>p</i> = 0.003). Cine-dynamic MRCP parameters improved after sphincterotomy in six patients.</p> Conclusions <p>Cine-dynamic MRCP enables non-invasive visualization and quantification of bile and pancreatic juice flow, providing functional assessment of the sphincter of Oddi.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Prospective pilot study of functional assessment of the Sphincter of Oddi via cine-dynamic MRCP with selective inversion recovery pulse

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月22日

查看全文
  • Yuki Oka,
  • Arata Sakai,
  • Atsuhiro Masuda,
  • Keitaro Sofue,
  • Shigeto Ashina,
  • Takashi Kobayashi,
  • Masahiro Tsujimae,
  • Masanori Gonda,
  • Noriko Inomata,
  • Mika Miki,
  • Yoshiyuki Harada,
  • Noriko Juri,
  • Yosuke Irie,
  • Tetsuhisa Ko,
  • Yusuke Yokotani,
  • Akira Shirohata,
  • Kaoruko Kanamaru,
  • Takafumi Tokunaga,
  • Kenta Yamamoto,
  • Kohei Okamoto,
  • Kento Ogawa,
  • Yuta Kawase,
  • Tatsuya Kageyama,
  • Ryuji Shimada,
  • Yuichiro Somiya,
  • Kentaro Nishiuchi,
  • Norimitsu Uza,
  • Yuzo Kodama

摘要

Background

Sphincter of Oddi dysfunction (SOD) can cause unexplained biliary pain and idiopathic pancreatitis. Although Rome IV criteria recommend sphincter of Oddi manometry (SOM) for diagnosis, SOM is invasive and carries pancreatitis risk. We hypothesized that cine-dynamic magnetic resonance cholangiopancreatography (MRCP) could non-invasively visualize bile and pancreatic juice flow, enabling functional papillary assessment.

Methods

In this prospective observational study, 40 participants were enrolled, and 29 were included in the final analysis after excluding 11 participants who did not meet the Rome IV criteria (10 healthy controls, 7 with suspected biliary-type SOD [BSOD], and 12 with suspected pancreatic-type SOD [PSOD]). Cine-dynamic MRCP was performed with 20 sequential frames over 5 min. Two quantitative indices were assessed: flow frequency and secretion grade (distance traveled by bile or pancreatic juice).

Results

Bile flow frequency and secretion grade were significantly lower in both BSOD and PSOD than in controls: frequency (median [range], 13.5 [6–19] in controls vs. 2.0 [1–17] in BSOD, p = 0.006; vs. 8.0 [3–14] in PSOD, p = 0.008) and secretion grade (1.6 [0.3–2.05] in controls vs. 0.2 [0.1–1.3] in BSOD, p = 0.001; vs. 0.5 [0.15–1.75] in PSOD, p = 0.03). Pancreatic juice flow showed no significant difference between BSOD and controls but was significantly reduced in PSOD: frequency (16 [14–19] in controls vs. 9.5 [4–17] in PSOD, p < 0.001) and secretion grade (2.15 [0.7–3.25] in controls vs. 0.98 [0.25–2.9] in PSOD, p = 0.003). Cine-dynamic MRCP parameters improved after sphincterotomy in six patients.

Conclusions

Cine-dynamic MRCP enables non-invasive visualization and quantification of bile and pancreatic juice flow, providing functional assessment of the sphincter of Oddi.