<p>Neurodegenerative disorders such as dementia and Alzheimer’s disease (AD) have adversely devastated the health and well-being of the older community. Given that early detection might help prevent or delay cognitive disorders associated with AD, developing an effective diagnostic technique is deemed appropriate to control the disease. Despite advances in clinical diagnostic standards and treatment techniques, the global prevalence of cognitive disturbance and behavioral problems remains steep. Besides the above challenge, the scarcity of AD-related open-source raw data prompted us to tailor ADNeuroNet, a neuroevolution-based neural network (NN) designed for predicting cognitively normal, mild cognitive impairment, and AD instances. To construct a robust NN algorithm that can predict the disease with high accuracy and improved efficiency, we worked on the combined cognitive and demographic clinical data to create a comprehensive model. Primarily, the Alzheimer’s Disease Neuroimaging Initiative (ADNI) repository was used to develop this program. We employed three distinct datasets and developed a predictive model that achieved the maximum performance accuracy of 93.42%. Utilizing only baseline details, the as-developed model successfully diagnosed and predicted neurodegenerative disorders and is likely to emerge as an effective clinical tool in future endeavors.</p>