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Purpose <p>Hematopoietic stem cell transplantation (HSCT) is a curative treatment for hematologic diseases. However, corticosteroids used to manage graft-versus-host disease can induce muscle weakness, particularly affecting fast-twitch fibers. The objective of this study was to examine the association between the total corticosteroid dose and the decline in fast-twitch muscle fibers, estimated using surface electromyography (sEMG), as well as to evaluate its impact on muscle strength and physical performance.</p> Methods <p>This prospective observational study included 53 adult patients from a single center in Japan. sEMG of the rectus femoris was performed before and after HSCT to calculate the median frequency (MF), a noninvasive marker of fast-twitch fiber proportion. Additional physical function assessments included isometric knee and hip flexion strength, handgrip strength, body weight, thigh circumference, 30-s chair stand test, and maximum walking speed. Correlations between total corticosteroid dose and changes in each variable were analyzed.</p> Results <p>Forty-two patients completed both the pre- and post-HSCT assessments. MF, muscle strength, body weight, thigh circumference, 30-s chair stand test performance, and maximum walking speed exhibited significant reductions (all <i>p</i> &lt; 0.01). The total corticosteroid dose negatively correlated with changes in MF (rs = -0.32), hip flexion strength (rs = −0.43), thigh circumference (rs = −0.32 to −0.40), and 30-s chair stand test performance (rs = −0.45).</p> Conclusions <p>A higher total corticosteroid dose after HSCT may lead to a reduced proportion of fast-twitch fibers, which could be associated with impairments in muscle strength and function.</p>

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Association between total corticosteroid dose and reduced fast-twitch rectus femoris muscle fibers after hematopoietic stem cell transplantation

  • 期刊论文

  • 发表日期：

    2026年5月22日

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  • Nobuyoshi Nishikado,
  • Tatsushi Wakasugi,
  • Katsuji Kaida,
  • Atsushi Umeji,
  • Koichiro Sota,
  • Daiki Takemura,
  • Kyohei Sugano,
  • Kazuki Eimoto,
  • Naoki Sasanuma,
  • Kyoko Yoshihara,
  • Satoshi Yoshihara,
  • Yuki Uchiyama,
  • Kazuhisa Domen

摘要

Purpose

Hematopoietic stem cell transplantation (HSCT) is a curative treatment for hematologic diseases. However, corticosteroids used to manage graft-versus-host disease can induce muscle weakness, particularly affecting fast-twitch fibers. The objective of this study was to examine the association between the total corticosteroid dose and the decline in fast-twitch muscle fibers, estimated using surface electromyography (sEMG), as well as to evaluate its impact on muscle strength and physical performance.

Methods

This prospective observational study included 53 adult patients from a single center in Japan. sEMG of the rectus femoris was performed before and after HSCT to calculate the median frequency (MF), a noninvasive marker of fast-twitch fiber proportion. Additional physical function assessments included isometric knee and hip flexion strength, handgrip strength, body weight, thigh circumference, 30-s chair stand test, and maximum walking speed. Correlations between total corticosteroid dose and changes in each variable were analyzed.

Results

Forty-two patients completed both the pre- and post-HSCT assessments. MF, muscle strength, body weight, thigh circumference, 30-s chair stand test performance, and maximum walking speed exhibited significant reductions (all p < 0.01). The total corticosteroid dose negatively correlated with changes in MF (rs = -0.32), hip flexion strength (rs = −0.43), thigh circumference (rs = −0.32 to −0.40), and 30-s chair stand test performance (rs = −0.45).

Conclusions

A higher total corticosteroid dose after HSCT may lead to a reduced proportion of fast-twitch fibers, which could be associated with impairments in muscle strength and function.