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Background <p>Anthropometry regarding muscle and fat is related to the mortality and quality of life in patients with cancer. We evaluated the role of muscle (hand grip strength, HGS) and fat (triceps skinfold thickness, TSF) in survival and quality of life among patients with cancer.</p> Methods <p>The study included 15,788 (53.9% men) patients with cancer from the Investigation on Nutrition Status and Clinical Outcome of Common Cancers Project of China. Outcomes included survival and health-related quality of life (QoL). Statistical analysis was performed using a maximally selected rank statistical method for sex-specific cutoff values. Cox analysis and Kaplan–Meier curves were used for survival analysis, and one-way ANOVA trend testing was used for quality of life.</p> Results <p>The patients’ mean age was 57.25 ± 11.66&#xa0;years. High TSF (adjusted HR = 0.77, 95% CI = 0.72–0.81, <i>P</i> &lt; 0.001) and high HGS (adjusted HR = 0.72, 95% CI = 0.68–0.76, <i>P</i> &lt; 0.001) were positively associated with survival. Patients with high TSF and low HGS (adjusted HR = 0.61, 95% CI = 0.54–0.68, <i>P</i> &lt; 0.001) had better survival than patients with low TSF and high HGS (adjusted HR = 0.73, 95% CI = 0.67–0.78, P &lt; 0.001). The quality of life of patients with high TSF and low HGS was also better than that of patients with low TSF and high HGS. The results were consistent in subgroup analyses of men and women and in sensitivity analyses that excluded patients who died within 6&#xa0;months.</p> Conclusions <p>TSF and HGS are positively associated with survival and quality of life. Considering the differences in TSF and HGS between men and women, fat mass is a better indicator of patients’ survival and quality of life than muscle function.</p>

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Subcutaneous adipose tissue outperforms muscle strength as an indicator of survival and quality of life in patients with cancer: a multicenter cohort study

  • 期刊论文

  • 发表日期：

    2026年5月21日

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  • Xiang-Ting Dai,
  • Xi Zhang,
  • Yi-Zhong Ge,
  • Chen-An Liu,
  • Hai-Hong Wang,
  • Ning Wang,
  • Jin Qin,
  • Chun-Hua Song,
  • Han-Ping Shi,
  • Ming-Hua Cong

摘要

Background

Anthropometry regarding muscle and fat is related to the mortality and quality of life in patients with cancer. We evaluated the role of muscle (hand grip strength, HGS) and fat (triceps skinfold thickness, TSF) in survival and quality of life among patients with cancer.

Methods

The study included 15,788 (53.9% men) patients with cancer from the Investigation on Nutrition Status and Clinical Outcome of Common Cancers Project of China. Outcomes included survival and health-related quality of life (QoL). Statistical analysis was performed using a maximally selected rank statistical method for sex-specific cutoff values. Cox analysis and Kaplan–Meier curves were used for survival analysis, and one-way ANOVA trend testing was used for quality of life.

Results

The patients’ mean age was 57.25 ± 11.66 years. High TSF (adjusted HR = 0.77, 95% CI = 0.72–0.81, P < 0.001) and high HGS (adjusted HR = 0.72, 95% CI = 0.68–0.76, P < 0.001) were positively associated with survival. Patients with high TSF and low HGS (adjusted HR = 0.61, 95% CI = 0.54–0.68, P < 0.001) had better survival than patients with low TSF and high HGS (adjusted HR = 0.73, 95% CI = 0.67–0.78, P < 0.001). The quality of life of patients with high TSF and low HGS was also better than that of patients with low TSF and high HGS. The results were consistent in subgroup analyses of men and women and in sensitivity analyses that excluded patients who died within 6 months.

Conclusions

TSF and HGS are positively associated with survival and quality of life. Considering the differences in TSF and HGS between men and women, fat mass is a better indicator of patients’ survival and quality of life than muscle function.