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Purpose <p>Sleep problems are a frequent concern of colorectal cancer (CRC) survivors. Research on modifiable lifestyle factors that may mitigate sleep problems is sparse. Therefore, we investigated how various body composition parameters are longitudinally associated with sleep problems from 6&#xa0;weeks up to 24&#xa0;months post-treatment.</p> Methods <p>In a prospective cohort of 396 stage I-III CRC survivors, home-based repeated measurements were conducted at diagnosis and at four post-treatment time points. The insomnia scale of the EORTC QLQ-C30 (range: 0–100) was used to measure sleep problems. Anthropometric measurements of adiposity (BMI, fat percentage, waist-hip ratio) and of muscle mass and muscle function (mid-upper arm muscle circumference, handgrip strength) were employed. Linear mixed models were applied to analyze overall longitudinal associations, and hybrid models were used to disentangle inter- and intra-individual components.</p> Results <p>At 6&#xa0;weeks post-treatment, 47.0% of participants reported sleep problems and symptom severity was at its highest; a decline was observed thereafter. In confounder-adjusted models, no statistically significant overall longitudinal associations of different body composition parameters with sleep problems were found. Intra-individual analyses revealed that increases in BMI were related to less sleep problems over time (<i>β</i> per 1&#xa0;kg/m<sup>2</sup>: -2.8, 95% CI -4.4; -1.2).</p> Conclusions <p>BMI increases in the first 24&#xa0;months post-treatment were associated with decreased sleep problems.</p> <p>These findings must be interpreted with caution due to the observational design, yet might suggest a potential link between weight regain and sleep problems among CRC survivors recovering from the physical and mental impact of cancer treatment.</p>

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Longitudinal associations of body composition with sleep problems in the first two years after colorectal cancer treatment

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月14日

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  • Ludovica Margotto,
  • Eline H. van Roekel,
  • Marlou-Floor Kenkhuis,
  • Stephanie O. Breukink,
  • Eric T. P. Keulen,
  • Maryska L. G. Janssen-Heijnen,
  • Ree Meertens,
  • Matty P. Weijenberg,
  • Martijn J. L. Bours

摘要

Purpose

Sleep problems are a frequent concern of colorectal cancer (CRC) survivors. Research on modifiable lifestyle factors that may mitigate sleep problems is sparse. Therefore, we investigated how various body composition parameters are longitudinally associated with sleep problems from 6 weeks up to 24 months post-treatment.

Methods

In a prospective cohort of 396 stage I-III CRC survivors, home-based repeated measurements were conducted at diagnosis and at four post-treatment time points. The insomnia scale of the EORTC QLQ-C30 (range: 0–100) was used to measure sleep problems. Anthropometric measurements of adiposity (BMI, fat percentage, waist-hip ratio) and of muscle mass and muscle function (mid-upper arm muscle circumference, handgrip strength) were employed. Linear mixed models were applied to analyze overall longitudinal associations, and hybrid models were used to disentangle inter- and intra-individual components.

Results

At 6 weeks post-treatment, 47.0% of participants reported sleep problems and symptom severity was at its highest; a decline was observed thereafter. In confounder-adjusted models, no statistically significant overall longitudinal associations of different body composition parameters with sleep problems were found. Intra-individual analyses revealed that increases in BMI were related to less sleep problems over time (β per 1 kg/m2: -2.8, 95% CI -4.4; -1.2).

Conclusions

BMI increases in the first 24 months post-treatment were associated with decreased sleep problems.

These findings must be interpreted with caution due to the observational design, yet might suggest a potential link between weight regain and sleep problems among CRC survivors recovering from the physical and mental impact of cancer treatment.