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Background <p>Dysphagia-induced malnutrition is a prevalent complication and critical determinant affecting the progression and prognosis of nasopharyngeal carcinoma (NPC) patients undergoing radiotherapy. This study retrospectively evaluates the efficacy of nasogastric tube nutrition support (NTNS) during NPC radiotherapy.</p> Methods <p>A retrospective observational cohort study was conducted on NPC patients who received radical chemoradiotherapy between January 2018 and December 2023, with complete medical records. Clinical and survival data were collected and analyzed to compare outcomes between the NTNS group and parenteral nutrition (PN) group.</p> Results <p>A total of 856 patients were enrolled (265 in NTNS group, 591 in PN group). Compared with the PN group, the NTNS group exhibited significantly lower rates of weight loss (2.23% vs. 4.82%, <i>P</i> = 0.027), PG-SGA scores (7.36 ± 0.58 vs. 8.65 ± 0.65, <i>P</i> = 0.021), severe malnutrition, grade 2+ oropharyngeal mucosal reactions (77.4% vs. 94.1%, <i>P</i> = 0.032), and infections (5.7% vs. 14.1%, <i>P</i> = 0.028). Additionally, the NTNS group showed higher levels of lymphocytes (<i>P</i> = 0.029), albumin (<i>P</i> = 0.035), and triceps skinfold thickness (<i>P</i> = 0.038). The incidence of nutritional risk was significantly lower in the NTNS group after radiotherapy (<i>P</i> &lt; 0.05). The NTNS group demonstrated a higher concurrent chemotherapy completion rate (92.9% vs. 72.0%, <i>P</i> &lt; 0.05), shorter radiotherapy duration, and better post-radiotherapy quality of life as assessed by EORTC QLQ-C30 (<i>P</i> &lt; 0.05). No significant difference was observed in short-term therapeutic efficacy between the groups.</p> Conclusion <p>NTNS during NPC radiotherapy is associated with reduced weight loss and severe malnutrition, delayed nutritional risk, alleviated radiotherapy-induced reactions, higher chemotherapy compliance, shortened treatment duration, and improved quality of life. These findings support integrating NTNS into standardized nutritional management for NPC patients undergoing radiotherapy.</p>

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Nasogastric tube nutrition support enhances chemoradiotherapy compliance and alleviates mucosal reactions in nasopharyngeal carcinoma: a 856-case retrospective cohort study

  • 期刊论文

  • 发表日期：

    2025年9月15日

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  • Xiang-ju Zeng,
  • Yi-fang Tang,
  • Jia-lai Zhan,
  • Yun-fei Li,
  • Fang-wen Zou

摘要

Background

Dysphagia-induced malnutrition is a prevalent complication and critical determinant affecting the progression and prognosis of nasopharyngeal carcinoma (NPC) patients undergoing radiotherapy. This study retrospectively evaluates the efficacy of nasogastric tube nutrition support (NTNS) during NPC radiotherapy.

Methods

A retrospective observational cohort study was conducted on NPC patients who received radical chemoradiotherapy between January 2018 and December 2023, with complete medical records. Clinical and survival data were collected and analyzed to compare outcomes between the NTNS group and parenteral nutrition (PN) group.

Results

A total of 856 patients were enrolled (265 in NTNS group, 591 in PN group). Compared with the PN group, the NTNS group exhibited significantly lower rates of weight loss (2.23% vs. 4.82%, P = 0.027), PG-SGA scores (7.36 ± 0.58 vs. 8.65 ± 0.65, P = 0.021), severe malnutrition, grade 2+ oropharyngeal mucosal reactions (77.4% vs. 94.1%, P = 0.032), and infections (5.7% vs. 14.1%, P = 0.028). Additionally, the NTNS group showed higher levels of lymphocytes (P = 0.029), albumin (P = 0.035), and triceps skinfold thickness (P = 0.038). The incidence of nutritional risk was significantly lower in the NTNS group after radiotherapy (P < 0.05). The NTNS group demonstrated a higher concurrent chemotherapy completion rate (92.9% vs. 72.0%, P < 0.05), shorter radiotherapy duration, and better post-radiotherapy quality of life as assessed by EORTC QLQ-C30 (P < 0.05). No significant difference was observed in short-term therapeutic efficacy between the groups.

Conclusion

NTNS during NPC radiotherapy is associated with reduced weight loss and severe malnutrition, delayed nutritional risk, alleviated radiotherapy-induced reactions, higher chemotherapy compliance, shortened treatment duration, and improved quality of life. These findings support integrating NTNS into standardized nutritional management for NPC patients undergoing radiotherapy.