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Purpose <p>The association of nutritional intervention and health-related quality of life (HRQL) was examined in children with cancer.</p> Methods <p>Undernourished children with cancer (<i>N</i> = 260) were randomized 1:1 to standard nutritional therapy (SNT) or SNT + Ready to Use Therapeutic Food (RUTF). HRQL was assessed using the Health Utilities Index® (HUI) at study entry and 6&#xa0;weeks later. HUI has two systems, HUI2 and HUI3, with derived categories of disability. Scores after SNT and SNT + RUTF were compared.</p> Results <p>At study entry there were no significant differences in HRQL scores between the two treatment arms. After 6&#xa0;weeks of nutritional intervention, median overall HUI2 scores were comparable—0.90 with RUTF and 0.89 with SNT (<i>p</i> = 0.317)—but overall HUI3 scores were 0.90 and 0.79 (<i>p</i> = 0.009), respectively. At study entry and 6&#xa0;weeks, 87 (35%) and 116 (46.6%) subjects had no or mild disability, and 162 (65%) and 133 (53.4%) had moderate or severe disability (<i>p</i> &lt; 0.001) respectively using HUI2 scores. Corresponding scores with HUI3 were 66 (26.5%) and 103 (41.3%) for no or mild disability and 183 (73.5%) and 146 (58.6%) (<i>p</i> &lt; 0.001) for moderate or severe disability at study entry and 6&#xa0;weeks, respectively.</p> <p>Children with weight gain &gt;10% had significant improvement in overall HUI2 (0.92 vs 0.84; <i>p</i> = 0.049) and HUI3 scores (0.88 vs 0.78; <i>p</i> = 0.010).</p> Conclusion <p>In severely and moderately malnourished children with cancer, administration of RUTF and weight gain were associated with improved HRQL. Weight gain can improve HRQL in numerous domains and overall.</p>

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Effective nutritional intervention improves the health-related quality of life (HRQL) of undernourished children with cancer: results of a randomized, controlled phase 3 trial

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  • 发表日期：

    2025年9月6日

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  • Maya Prasad,
  • Savita Goswami,
  • Girish Chinnaswamy,
  • Elena J. Ladas,
  • Ronald D. Barr

摘要

Purpose

The association of nutritional intervention and health-related quality of life (HRQL) was examined in children with cancer.

Methods

Undernourished children with cancer (N = 260) were randomized 1:1 to standard nutritional therapy (SNT) or SNT + Ready to Use Therapeutic Food (RUTF). HRQL was assessed using the Health Utilities Index® (HUI) at study entry and 6 weeks later. HUI has two systems, HUI2 and HUI3, with derived categories of disability. Scores after SNT and SNT + RUTF were compared.

Results

At study entry there were no significant differences in HRQL scores between the two treatment arms. After 6 weeks of nutritional intervention, median overall HUI2 scores were comparable—0.90 with RUTF and 0.89 with SNT (p = 0.317)—but overall HUI3 scores were 0.90 and 0.79 (p = 0.009), respectively. At study entry and 6 weeks, 87 (35%) and 116 (46.6%) subjects had no or mild disability, and 162 (65%) and 133 (53.4%) had moderate or severe disability (p < 0.001) respectively using HUI2 scores. Corresponding scores with HUI3 were 66 (26.5%) and 103 (41.3%) for no or mild disability and 183 (73.5%) and 146 (58.6%) (p < 0.001) for moderate or severe disability at study entry and 6 weeks, respectively.

Children with weight gain >10% had significant improvement in overall HUI2 (0.92 vs 0.84; p = 0.049) and HUI3 scores (0.88 vs 0.78; p = 0.010).

Conclusion

In severely and moderately malnourished children with cancer, administration of RUTF and weight gain were associated with improved HRQL. Weight gain can improve HRQL in numerous domains and overall.