Purpose <p>Cancer is a significant public health issue, and with rising living standards, patients increasingly prioritize quality of life. This has heightened the demand for spiritual care. Despite its proven benefits, research on spiritual care experiences in China remains limited. This study aims to explore Chinese nurses’ experiences in providing spiritual care to cancer patients.</p> Method <p>Semi-structured face-to-face interviews were conducted with 15 purposively sampled nurses from a tertiary oncology hospital in China during May 2023. This study employed a combined approach of induction and deduction in content analysis to analyze the data.</p> Results <p>Four key themes emerged: (1) experiences and needs related to spiritual care training, (2) emotional resonance in spiritual care, (3) the dual benefits of spiritual care for both nurses and patients, and (4) dual-dimensional influencing factors in spiritual care implementation, including caregiver-related and patient-related factors.</p> Conclusions <p>This study emphasizes the necessity of culturally adaptive spiritual care training in Chinese oncology nursing and its dual benefits. China’s humanistic approach holds unique value compared to Western religious models. Despite multiple challenges, there is significant development space. Integrating spiritual care with cultural norms can enhance patient outcomes and nurses’ growth, calling for flexible and standardized protocols to ensure broader applicability.</p>