Purpose <p>This study was aimed to investigate the impact of Timing it Right Brain Tumor Support Program (TIRBTSP) on clinical outcome for patients diagnosed with sellar region tumors.</p> Methods <p>This study adopted a prospective historical control study to compare and analyze the application effect of the TIR theory in patients with sellar region tumors treated by neuroendoscopic endonasal approach. The control group included patients admitted from April to May 2023, while the intervention group consisted of patients admitted from November to December 2023. The intervention group received TIRBTSP intervention (<i>n</i> = 40), and the control group received routine nursing intervention (<i>n</i> = 40). Assessments were conducted at baseline, before discharge, and 30&#xa0;days after discharge. Discharge readiness and discharge guidance were evaluated using the Readiness for Hospital Discharge Scale (RHDS) and the Quality of Discharge Teaching Scale (QDTS), respectively.</p> Results <p>The findings of the study demonstrated that the total score of discharge readiness, coping ability, and expected support score were all elevated in the experimental group in comparison to the control group. Significant disparities were identified between the intervention and control groups in the total score of discharge teaching quality evaluation, the actual content received, and the effectiveness of teaching techniques, exhibiting statistically higher values in the group as compared to the control group. Additionally, the readmission rate within 30&#xa0;days in the intervention group was lower than that in the control group; there is no significant difference in the length of hospital stay between the two groups.</p> Conclusion <p>An effective TIRBTSP intervention plays a pivotal role in enhancing the discharge readiness of patients, mitigating the occurrence of short-term complications among individuals diagnosed with sellar tumors, and facilitating their overall recovery.</p>