Purpose <p>Despite the availability of resources to support advance care planning (ACP) among people from ethnic minority backgrounds, its uptake remains low among these communities presenting an ACP implementation gap. This study was conducted to understand barriers and facilitators in service delivery experienced by healthcare staff and interpreters involved in implementing ACP with people from ethnic minority backgrounds with cancer.</p> Methods <p>A qualitative study using focus groups and semi-structured interviews was conducted with eligible healthcare staff and interpreters. Data was analysed employing the Framework Method using the Theoretical Domains Framework to understand ACP implementation factors.</p> Results <p>Eight focus groups comprising 28 participants and three individual semi-structured interviews were conducted. Four themes were developed, along with an underpinning theme of interprofessional collaboration between clinicians and interpreters in ACP. The four themes were as follows: (1) skills of the healthcare clinicians and interpreters; (2) knowledge of cultural factors that impact ACP; (3) the care setting and the physical environment for ACP; and (4) availability of resources to support ACP. Opportunities to foster interprofessional collaboration between clinicians and interpreters, such as training in working with each other and briefing and debriefing, were not available.</p> Conclusions <p>Shared understanding between interpreters and cancer clinicians about their communication approach and terminologies to use when no direct translation is available may contribute towards increased uptake of ACP. Identification and necessary adaptations of mechanisms that foster interprofessional collaboration in cancer care between clinicians and interpreters in ACP communication with ethnic minority communities will enhance ACP uptake and person-centred care.</p>