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Purpose <p>To examine the occurrence, timing, and radiation dose associated with oral mucositis (OM) and body weight change in patients who underwent head and neck radiotherapy (RT) using the Volumetric Modulated Arc Therapy (VMAT) technique. It was also investigated whether these side effects affected nutritional status.</p> Methods <p>Data regarding age, gender, tumor type, radiation doses, OM, weight loss, diet, and prescriptions for nasoenteral tubes and gastrostomy were collected retrospectively from 84 medical records of a single head and neck VMAT service.</p> Results <p>Severe OM was observed in 61.8% of patients, occurring at a median cumulative dose of 37.7&#xa0;Gy. Severe OM was significantly associated with radiation doses to the oral cavity and with concurrent chemotherapy, the latter being identified as a predictive factor. A median body weight loss of 6.1&#xa0;kg was found in the majority of patients. Severe OM was linked with weight loss and the need for artificial nutrition.</p> Conclusion <p>The frequency of OM in the oral cavity was high in patients treated with VMAT, significantly impacting nutritional status. Radiation dose to the oral mucosa and concurrent chemotherapy were associated with severe OM.</p>

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Daily assessment of oral mucositis during volumetric modulated arc therapy planning technique for head and neck cancer: risk factors and impact on nutritional status

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • Marcella Ferreira Gobbi,
  • Fernanda de Paula Eduardo,
  • Letícia Mello Bezinelli,
  • Lívia Goron Bergamin,
  • Danielle Lima Correa de Carvalho,
  • Carolina Moreno dos Santos,
  • Eduardo Weltman,
  • Luciana Corrêa

摘要

Purpose

To examine the occurrence, timing, and radiation dose associated with oral mucositis (OM) and body weight change in patients who underwent head and neck radiotherapy (RT) using the Volumetric Modulated Arc Therapy (VMAT) technique. It was also investigated whether these side effects affected nutritional status.

Methods

Data regarding age, gender, tumor type, radiation doses, OM, weight loss, diet, and prescriptions for nasoenteral tubes and gastrostomy were collected retrospectively from 84 medical records of a single head and neck VMAT service.

Results

Severe OM was observed in 61.8% of patients, occurring at a median cumulative dose of 37.7 Gy. Severe OM was significantly associated with radiation doses to the oral cavity and with concurrent chemotherapy, the latter being identified as a predictive factor. A median body weight loss of 6.1 kg was found in the majority of patients. Severe OM was linked with weight loss and the need for artificial nutrition.

Conclusion

The frequency of OM in the oral cavity was high in patients treated with VMAT, significantly impacting nutritional status. Radiation dose to the oral mucosa and concurrent chemotherapy were associated with severe OM.