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Purpose <p>To evaluate periodontal health after allogeneic haematopoietic cell transplantation (HCT), and its association with conditioning regimen intensity.</p> Methods <p>This single-centre retrospective cohort study included 82 allogeneic HCT recipients between 01/08/2017 and 31/03/2022. Probing pocket depth (PPD), bleeding on probing (BOP), periodontal epithelial surface area (PESA) and periodontal inflamed surface area (PISA) were assessed pre- and post-HCT. Change scores were calculated, and regression models were applied to analyse associations with conditioning intensity. Conditioning regimens were categorised based on intensity as non-myeloablative (NMA), reduced intensity (RIC) or myeloablative (MA).</p> Results <p>HCT recipients had a median age of 59&#xa0;years (IQR 48–66); 63% were male. Median time to HCT was 53&#xa0;days (IQR 29–89), median follow-up was 279&#xa0;days (IQR 183–349). Severe periodontitis (≥ 1 site with PPD ≥ 6&#xa0;mm) was observed in 37% of patients pre-HCT and 20% of patients post-HCT. PPD, BOP, PESA and PISA decreased from pre- to post-HCT, by 0.26&#xa0;mm [95%CI 0.16;0.37], 8% [95%CI 5;12], 140 mm<sup>2</sup> [95%CI 89;190] and 123 mm<sup>2</sup> [95%CI 83;185], respectively. Prevalence of severe periodontitis decreased from pre- to post-HCT in all groups: NMA 50% to 27%, RIC 32% to 19%, MA 31% to 13%. Conditioning intensity was statistically significantly associated with post-HCT PPD and PESA; however, differences were small. No statistically significant differences were observed in post-HCT PISA between conditioning regimens.</p> Conclusion <p>Periodontal health improved marginally in the short-term following HCT and supportive oral care. Differences in post-HCT periodontal health between patients conditioned with NMA, RIC, and MA were not clinically relevant.</p>

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Periodontal changes after haematopoietic cell transplantation and the role of conditioning regimen intensity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月23日

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  • Lucky L. A. van Gennip,
  • Marjolein S. Bulthuis,
  • Gerjon Hannink,
  • Ewald M. Bronkhorst,
  • Stephanie J. M. van Leeuwen,
  • Nicole M. A. Blijlevens,
  • Marie-Charlotte D. N. J. M. Huysmans,
  • Renske Z. Thomas

摘要

Purpose

To evaluate periodontal health after allogeneic haematopoietic cell transplantation (HCT), and its association with conditioning regimen intensity.

Methods

This single-centre retrospective cohort study included 82 allogeneic HCT recipients between 01/08/2017 and 31/03/2022. Probing pocket depth (PPD), bleeding on probing (BOP), periodontal epithelial surface area (PESA) and periodontal inflamed surface area (PISA) were assessed pre- and post-HCT. Change scores were calculated, and regression models were applied to analyse associations with conditioning intensity. Conditioning regimens were categorised based on intensity as non-myeloablative (NMA), reduced intensity (RIC) or myeloablative (MA).

Results

HCT recipients had a median age of 59 years (IQR 48–66); 63% were male. Median time to HCT was 53 days (IQR 29–89), median follow-up was 279 days (IQR 183–349). Severe periodontitis (≥ 1 site with PPD ≥ 6 mm) was observed in 37% of patients pre-HCT and 20% of patients post-HCT. PPD, BOP, PESA and PISA decreased from pre- to post-HCT, by 0.26 mm [95%CI 0.16;0.37], 8% [95%CI 5;12], 140 mm2 [95%CI 89;190] and 123 mm2 [95%CI 83;185], respectively. Prevalence of severe periodontitis decreased from pre- to post-HCT in all groups: NMA 50% to 27%, RIC 32% to 19%, MA 31% to 13%. Conditioning intensity was statistically significantly associated with post-HCT PPD and PESA; however, differences were small. No statistically significant differences were observed in post-HCT PISA between conditioning regimens.

Conclusion

Periodontal health improved marginally in the short-term following HCT and supportive oral care. Differences in post-HCT periodontal health between patients conditioned with NMA, RIC, and MA were not clinically relevant.