Introduction <p>Patients with head and neck squamous cell carcinoma (HNSCC) are at risk for long-term side effects and require thorough survivorship care following completion of radiation therapy (RT). We aimed to identify survivorship interest and needs following RT.</p> Methods <p>Patients with HNSCC who completed RT from Jan 2013 to April 2023 completed questions based on the five-domain Cancer Survivorship Framework (physical effects, psychosocial effects, cancer screening, chronic conditions, health promotion) and the Consolidated Framework for Implementation Research (interest, knowledge, barriers).</p> Results <p>Of 1,123 patients, 317 participated (response rate 28%). Patients were 64% (<i>n</i> = 203) male with a mean age of 64&#xa0;years (SD 12), with 66% (<i>n</i> = 209) finishing treatment &gt; 2-years prior. 36% (<i>n</i> = 115) were interested in, 34% (<i>n</i> = 108) prioritized, and 28% (<i>n</i> = 88) had information related to survivorship. For survivorship domains, within physical effects, dry mouth (40%, <i>n</i> = 126) and trouble swallowing (24%, <i>n</i> = 75) were most bothersome. For psychosocial, 15% (<i>n</i> = 46) reported current depression (mean PHQ2 score ≥ 3) and 71% (<i>n</i> = 226) felt mental health needs were not addressed during treatment. Forty-two percent felt that diet, exercise, and smoking were not addressed (<i>n</i> = 134). Seventy-six percent (<i>n</i> = 240) understood the importance of cancer screening. Most patients wished to address survivorship topics in one long visit (45%, <i>n</i> = 142) and preferred in-person visits (60%, <i>n</i> = 190). Potential barriers included insurance coverage and scheduling concerns.</p> Conclusion <p>In post-RT HNSCC survivors, survivorship interest and knowledge were limited. There is a need for education on survivorship.</p> Implications <p>These findings provide a foundation for developing robust survivorship care programs that meet the diverse needs of this patient population.</p>