Objective <p>Patients with hematological tumors frequently experience lower life satisfaction, highlighting the need to identify factors that can increase well-being. This research investigated the influence of family support on the life satisfaction of hematologic cancer patients, considering the mediating role of hope.</p> Methods <p>In this cross-sectional study, 322 patients with hematologic tumors completed a series of questionnaires on demographic information, family support, the hope index, and life satisfaction. A structural equation model is established to evaluate the mediating effect between variables.</p> Results <p>The structural equation model fits well. Family support significantly positively predicted hope and life satisfaction (<i>β</i> = 0.54, <i>p</i> &lt; 0.001; <i>β</i> = 0.19, <i>p</i> &lt; 0.01), and hope significantly positively predicted life satisfaction (<i>β</i> = 0.45, <i>p</i> &lt; 0.001).</p> Conclusions <p>A significant positive correlation was observed between the degree of family support and life satisfaction among patients with hematological tumors. Moreover, hope serves as a partial mediator in the connection between life satisfaction and family support for such patients, suggesting that family support indirectly impacts life satisfaction by nurturing hope.</p>