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Background <p>Advances in anticancer treatments have significantly improved disease control and progression-free survival. These therapies are associated with various adverse events (AEs), especially cutaneous toxicities. However, there is a paucity of patient-reported outcomes on cutaneous AEs (CAEs) and associated alternation of quality of life (QoL) in cancer patients.</p> Objective <p>To evaluate the impact of CAEs on QoL and related social factors in cancer patients.</p> Methods <p>A cross-sectional questionnaire-based study was conducted in Huashan Hospital affiliated with Fudan University, Fudan University Shanghai Cancer Center, and Zhongshan Hospital affiliated with Fudan University. This study utilized a patient-based questionnaire including social factors, skincare routines, incidence of CAEs, and the impact on QoL.</p> Results <p>Of the 1004 survey participants, 599 reported suffering from CAEs after targeted therapies. The majority of participants were female. Breast cancer was the most frequently reported cancer type. Itching was the most frequently reported problem, followed by eczema, hair loss, hand-foot reaction syndrome, and dry skin. Female participants had significantly lower DLQI scores than males. The need for multidisciplinary approaches in managing skin adverse events was emphasized by 78.30% of participants.</p> Conclusion <p>Patient self-report is critical to early detection and proper management for CAEs in cancer patients receiving novel anticancer therapies, thus improving patients’ prognosis and QoL. Furthermore, our study emphasized the importance of closer collaboration between dermatologists and oncologists.</p>

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A questionnaire-based cross-sectional survey of cutaneous adverse events in cancer patients treated with molecular targeted therapy and immunotherapies

  • 期刊论文

  • 发表日期：

    2025年3月8日

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  • Shan He,
  • Fanping Yang,
  • Lichen Tang,
  • Jin Yang,
  • Shengan Chen,
  • Zihua Chen,
  • Lanting Wang,
  • Zhen Zhang,
  • Li Ma,
  • Xiaoqun Luo

摘要

Background

Advances in anticancer treatments have significantly improved disease control and progression-free survival. These therapies are associated with various adverse events (AEs), especially cutaneous toxicities. However, there is a paucity of patient-reported outcomes on cutaneous AEs (CAEs) and associated alternation of quality of life (QoL) in cancer patients.

Objective

To evaluate the impact of CAEs on QoL and related social factors in cancer patients.

Methods

A cross-sectional questionnaire-based study was conducted in Huashan Hospital affiliated with Fudan University, Fudan University Shanghai Cancer Center, and Zhongshan Hospital affiliated with Fudan University. This study utilized a patient-based questionnaire including social factors, skincare routines, incidence of CAEs, and the impact on QoL.

Results

Of the 1004 survey participants, 599 reported suffering from CAEs after targeted therapies. The majority of participants were female. Breast cancer was the most frequently reported cancer type. Itching was the most frequently reported problem, followed by eczema, hair loss, hand-foot reaction syndrome, and dry skin. Female participants had significantly lower DLQI scores than males. The need for multidisciplinary approaches in managing skin adverse events was emphasized by 78.30% of participants.

Conclusion

Patient self-report is critical to early detection and proper management for CAEs in cancer patients receiving novel anticancer therapies, thus improving patients’ prognosis and QoL. Furthermore, our study emphasized the importance of closer collaboration between dermatologists and oncologists.