Purpose <p>The primary purpose was to assess the feasibility and acceptability of a group health coaching (GHC) program with cancer patients and survivors; secondarily, to determine the preliminary effects of GHC on several behavioral lifestyle factors.</p> Methods <p>GHC was provided to people diagnosed with cancer via videoconference by trained health coaches across six GHC sessions over a 3-month period. Qualitative and quantitative data were collected. Data on recruitment, attrition, attendance, fidelity, retention, safety, and barriers and facilitators to implementation were assessed. Participant-reported outcomes collected via surveys included physical activity, eating habits, perceived stress, anxiety, depression, sleep, and quality of life, followed by post-program focus groups and in-depth interviews. Survey results were analyzed using repeated measures multilevel modeling. Qualitative data was analyzed using inductive thematic analysis.</p> Results <p>Overall, 26 participants with a variety of cancer types attended an average of 74% of coaching sessions. The intervention was feasible to implement and found acceptable by participants and health coaches. Over the course of the intervention, there was a moderate increase in total weekly physical activity minutes (baseline = 365.25, follow-up = 510.30, <i>p</i> = 0.032, <i>d</i> = 0.50), and a small increase in weekly moderate-vigorous physical activity frequency (baseline = 4.07 bouts, follow-up = 5.44 bouts, <i>p</i> = 0.045, <i>d</i> = 0.39). Additionally, a moderate increase was found in functional well-being (baseline = 16.30, follow-up = 18.93, <i>p</i> &lt; 0.001, <i>d</i> = 0.50).</p> Conclusions&#xa0;and implications <p>GHC may be a feasible and acceptable way to promote behavior change for physical activity in cancer patients and survivors, reducing cancer burden and enhancing functional well-being.</p>