StrataXRT for the prevention of acute radiation dermatitis in breast cancer: a pilot study

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发表日期：

2024年9月18日

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Samantha K. F. Kennedy,
Milena Gojsevic,
Thenugaa Rajeswaran,
Liying Zhang,
Olivia Kuszaj,
Marley Day,
Irene Karam,
Danny Vesprini,
Eric Leung,
Ewa Szumacher,
Eileen Rakovitch,
Hany Soliman,
Hanbo Chen,
Shing Fung Lee,
Tara Behroozian,
William Tran,
Matt Wronski,
Francois Gallant,
Katherine Carothers,
Tiegsti Yewhans,
Cindy Wong,
Henry Wong,
Edward Chow

摘要

Purpose

Previous literature has produced heterogeneous results on StrataXRT for prevention of acute radiation dermatitis (RD) in breast cancer. This pilot study aimed to assess the feasibility and efficacy of StrataXRT in a cancer center.

Methods

The study consisted of five cohorts: (1) patients with large breasts treated with local radiation therapy (RT) either in the supine position or (2) the prone position, (3) patients receiving locoregional breast RT with any breast size, and (4) patients receiving chest wall RT, either locally or (5) locoregionally. The primary endpoint of the study was RD grade as assessed using the Common Terminology Criteria for Adverse Events. Secondary endpoints included incidence of moist desquamation (MD), patient- and clinician-reported skin assessments, patient quality of life as assessed by the Skindex-16, and patient satisfaction. These outcomes were compared with those from a published trial from the same institution assessing standard of care and Mepitel Film (MF) as prevention of breast RD.

Results

Forty-five patients receiving RT to the breast or chest wall were enrolled. Two withdrew, leaving 43 evaluable patients. Overall, two (4.7%) patients had grade 3 RD, 14 (32.6%) had grade 2 RD, and 27 (62.8%) had grade 1 RD. Ten patients (23.3%) developed MD during/after RT.

Conclusion

StrataXRT is effective in preventing grade 3 RD in patients, and the most promising results were observed within the prone cohort. Further research includes evaluating the efficacy of StrataXRT against the standard of care for the prophylaxis of RD.

Trial registration

The study protocol was registered at ClinicalTrials.gov (identifier: NCT05594498) on October 13, 2022.