Functional quality of life among newly diagnosed young adult colorectal cancer survivors compared to older adults: results from the ColoCare Study

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2024年4月19日

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Laura B. Oswald,
Amanda Bloomer,
Xiaoyin Li,
Esther Jean-Baptiste,
Gillian Trujillo,
Seth Felder,
Brent J. Small,
Jennifer Ose,
Sheetal Hardikar,
Ildiko Strehli,
Lyen C. Huang,
Kathi Mooney,
Matthew G. Mutch,
Dante Chao,
Stacey A. Cohen,
Meghana Karchi,
Elizabeth H. Wood,
Victoria Damerell,
Nicole C. Loroña,
Jun Gong,
Adetunji T. Toriola,
Christopher I. Li,
David Shibata,
Martin Schneider,
Biljana Gigic,
Jane C. Figueiredo,
Heather S. L. Jim,
Cornelia M. Ulrich,
Erin M. Siegel

摘要

Purpose

Colorectal cancer (CRC) incidence and mortality are increasing among young adults (YAs) aged 18–39. This study compared quality of life (QOL) between YA and older adult CRC survivors in the ColoCare Study.

Methods

Participants were grouped by age (years) as follows: 18–39 (YA), 40–49, 50–64, and 65 + . Functional QOL (physical, social, role, emotional, cognitive) and global QOL were assessed with the EORTC-QLQ-C30 at enrollment, 3, 6, and 12 months. Average scores were compared between groups over time using longitudinal mixed-effect modeling. Proportions with clinically meaningful QOL impairment were calculated using age-relevant thresholds and compared between groups over time using logistic regression with mixed effects.

Results

Participants (N = 1590) were n = 81 YAs, n = 196 aged 40–49, n = 627 aged 50–64, and n = 686 aged 65 + . Average physical function was better among YAs than participants aged 50–64 (p = 0.010) and 65 + (p < 0.001), and average social function was worse among YAs than aged 65 + (p = 0.046). Relative to YAs, all age groups were less likely to report clinically meaningful social dysfunction (aged 40–49 OR = 0.13, 95%CI = 0.06–0.29; aged 50–64 OR = 0.10, 95%CI = 0.05–0.21; aged 65 + OR = 0.07, 95%CI = 0.04–0.15) and role dysfunction (aged 40–49 OR = 0.36, 95%CI = 0.18–0.75; aged 50–64 OR = 0.41, 95%CI = 0.22–0.78; aged 65 + OR = 0.32, 95%CI = 0.17–0.61). Participants aged 40–49 were also less likely to report physical dysfunction (OR = 0.42, 95%CI = 0.19–0.93).

Conclusion

YA CRC survivors reported better physical and worse social function compared to older CRC survivors, and YA CRC survivors were more likely to report clinically meaningful social, role, and physical disfunction. Future work should further investigate QOL using age-relevant benchmarks to inform best practices for CRC survivorship care.

Trial registration

NCT02328677, registered December 2014.