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<p>Iron deficiency (ID) is a common comorbidity in heart failure (HF), affecting 55% of chronic and up to 80% of acute HF patients, regardless of ejection fraction (EF). An ID is associated with reduced quality of life, impaired exercise capacity (VO<sub>2</sub> peak), higher hospitalization rate and lower survival rate. It is also an independent predictor of HF outcomes. This consensus statement critically reviews the diagnostic criteria for ID in HF and provides recommendations for their use. The efficacy and safety of intravenous iron supplements, including ferric carboxymaltose (FCM) and ferric derisomaltose (FDI), are analyzed highlighting the indications and potential adverse effects. Key clinical trials and guideline recommendations are summarized. In summary, the document addresses the diagnostics, treatment and monitoring of ID in HF.</p>

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Diagnosis and treatment of iron deficiency in chronic heart failure

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月6日

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  • Moritz Messner,
  • Gerhard Pölzl,
  • Christopher Adlbrecht,
  • Johann Altenberger,
  • Johann Auer,
  • Robert Berent,
  • Jakob Dörler,
  • Marc-Michael Zaruba,
  • Christian Ebner,
  • Friedrich Fruhwald,
  • Martin Hülsmann,
  • Deddo Mörtl,
  • Peter P. Rainer,
  • Anna Rab,
  • Thomas Weber,
  • Rudolf Berger

摘要

Iron deficiency (ID) is a common comorbidity in heart failure (HF), affecting 55% of chronic and up to 80% of acute HF patients, regardless of ejection fraction (EF). An ID is associated with reduced quality of life, impaired exercise capacity (VO2 peak), higher hospitalization rate and lower survival rate. It is also an independent predictor of HF outcomes. This consensus statement critically reviews the diagnostic criteria for ID in HF and provides recommendations for their use. The efficacy and safety of intravenous iron supplements, including ferric carboxymaltose (FCM) and ferric derisomaltose (FDI), are analyzed highlighting the indications and potential adverse effects. Key clinical trials and guideline recommendations are summarized. In summary, the document addresses the diagnostics, treatment and monitoring of ID in HF.