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<p>Long-term heat exposure as a result of global warming, has become a threat to the overall human well-being and in particular the reproductive health of females. This research, therefore, investigated the ameliorative effect of <i>Amaranthus hybridus</i> aqueous leaf extract on the ovarian function of rats exposed to heat for 21 days. Twenty (20) healthy female rats of Wistar strain were randomly distributed into control group (distilled water), heat-exposed rats (group 2) were exposed to 39–40&#xa0;°C heat for 4&#xa0;h/day using two (100 Watts) bulbs to produce heat, group 3 animals were exposed to heat and administered with 55&#xa0;mg/kg bw of <i>A. hybridus</i> aqueous leaf extract, while group 4 received only <i>A. hybridus</i> aqueous leaf extract. The experiment was for 21 days. From the result, heat exposure caused a decrease in the body weight, protein level as well as decrease in the levels of antioxidant molecules superoxide dismutase (SOD), catalase (CAT)), reduced glutathione (GSH), and nuclear factor erythroid 2-related factor 2 (Nrf2). There was an increase in the levels of cortisol, malondialdehyde (MDA) and nitric oxide (NO) in the animals exposed to heat. However, when the animals were administered with <i>A. hybridus</i> extract had reduced MDA and cortisol and increase in catalase and SOD activity as well as the LH and prolactin levels. The findings of the study indicated the occurrence of oxidative damage and suggested that extended exposure to high temperatures had disadvantageous impacts on the animals.</p>

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Amaranthus hybridus improved heat-induced oxidative stress and hormonal alterations in rat ovaries

  • 期刊论文

  • 发表日期：

    2026年2月18日

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  • Tomilola Debby Olaolu,
  • Teniola Esther Durojaiye,
  • Ukpanyang Otu Joseph,
  • Tinuola Owoso,
  • Damilare Emmanuel Rotimi,
  • Oluyomi Stephen Adeyemi

摘要

Long-term heat exposure as a result of global warming, has become a threat to the overall human well-being and in particular the reproductive health of females. This research, therefore, investigated the ameliorative effect of Amaranthus hybridus aqueous leaf extract on the ovarian function of rats exposed to heat for 21 days. Twenty (20) healthy female rats of Wistar strain were randomly distributed into control group (distilled water), heat-exposed rats (group 2) were exposed to 39–40 °C heat for 4 h/day using two (100 Watts) bulbs to produce heat, group 3 animals were exposed to heat and administered with 55 mg/kg bw of A. hybridus aqueous leaf extract, while group 4 received only A. hybridus aqueous leaf extract. The experiment was for 21 days. From the result, heat exposure caused a decrease in the body weight, protein level as well as decrease in the levels of antioxidant molecules superoxide dismutase (SOD), catalase (CAT)), reduced glutathione (GSH), and nuclear factor erythroid 2-related factor 2 (Nrf2). There was an increase in the levels of cortisol, malondialdehyde (MDA) and nitric oxide (NO) in the animals exposed to heat. However, when the animals were administered with A. hybridus extract had reduced MDA and cortisol and increase in catalase and SOD activity as well as the LH and prolactin levels. The findings of the study indicated the occurrence of oxidative damage and suggested that extended exposure to high temperatures had disadvantageous impacts on the animals.