<p>This review aims to explore the impact of natural environmental factors on human health and cardiovascular pathology. The precise ways in which complex life forms adapted to these factors remain unclear. However, it is known that Homo sapiens evolved cardiovascular and neurological systems, which generate electromagnetic fields as part of their function. It is still uncertain how the human body may have utilized external electromagnetic fields to regulate its processes. Additionally, we will discuss the mechanisms related to environmental factors that may have influenced evolutionary pathways. This review paper also examines the impact of oscillations in natural environmental factors on human chrono-periodic systems. The human body is influenced by various fluctuations in both external and internal factors, some of which can potentially disrupt homeostasis. Animals and humans have the ability to anticipate external signal. The chrono-periodic system of the human body is responsible for this “premonition”. It would be incorrect to assume that specific reactions to each stimulus were fully developed and fixed during evolution. Except for genetic defects, it is unlikely that the human body evolved to have fixed pathological reactions, as this would contradict the principles of natural selection. Therefore, all typical responses of the human body to stimuli should be considered physiological, meaning they are adaptive.</p>