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<p>Hyperuricemia is a common finding in kidney transplant recipients, often associated with calcineurin inhibitor or diuretic use, obesity, metabolic syndrome, dyslipidemia, high purine intake, and reduced allograft function. We report a unique case of hyperuricemia leading to acute kidney injury associated with the use of cimetidine for treatment of mosaic warts in a 12-year-old female pediatric kidney transplant patient. With the reduction in the patient’s serum uric acid levels, there was concurrent marked improvement in her eGFR. Subsequently, her uric acid remained low, suggesting the cessation of cimetidine maintained her baseline uric acid level. This case highlights the significance of monitoring uric acid levels post-transplant and the importance of attention to potential drug interactions.</p>

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A rare case of hyperuricemia and acute kidney injury in a kidney transplant patient

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月13日

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  • Anna S. Nidhiry,
  • Dechu Puliyanda,
  • Cindy Blifeld,
  • Helen Pizzo

摘要

Hyperuricemia is a common finding in kidney transplant recipients, often associated with calcineurin inhibitor or diuretic use, obesity, metabolic syndrome, dyslipidemia, high purine intake, and reduced allograft function. We report a unique case of hyperuricemia leading to acute kidney injury associated with the use of cimetidine for treatment of mosaic warts in a 12-year-old female pediatric kidney transplant patient. With the reduction in the patient’s serum uric acid levels, there was concurrent marked improvement in her eGFR. Subsequently, her uric acid remained low, suggesting the cessation of cimetidine maintained her baseline uric acid level. This case highlights the significance of monitoring uric acid levels post-transplant and the importance of attention to potential drug interactions.