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Background <p>Numerous studies have confirmed that the NOSES has significant short-term prognostic benefits in the treatment of CRC. However, there is still an obvious gap in the systematic assessment of the psychological status of patients in the perioperative period, such as anxiety and depression. Our study aims to compare the quality of life and psychological functions, as well as the short-term surgical outcomes in patients undergoing NOSES and conventional laparoscopic surgery.</p> Methods <p>This prospective study included patients diagnosed with CRC who underwent radical resection between January 2021 and August 2024 at Sechenov University and Harbin Medical University. Patients were segregated into NOSES group and CL group based on case-match method. Quality of life was assessed using the Short-Form 36 Health Survey (SF-36), Beck Depression Inventory (BDI) and Spielberger State-Trait Anxiety Inventory (STAI) preoperative, predischarge, postoperative 3&#xa0;months and postoperative 6&#xa0;months.</p> Results <p>A total of 92 patients (46 in the NOSES group and 46 in the CL group) were included. The NOSES group showed faster gastrointestinal recovery and subsequently shorter hospital stays than the CL group. Postoperative pain scores were significantly lower in the NOSES group on the first, third and fifth postoperative days. At three months postoperatively, role function, physical pain, vitality, emotional state and mental health were better in the NOSES group than in the CL group. In addition, patients in the NOSES group had better role function, physical pain, vitality, social function, emotional state and mental health than patients in the CL group. As for postoperative anxiety and depression, patients in the NOSES group were significantly better than patients in the CL group before discharge, three months after surgery and six months after surgery.</p> Conclusion <p>NOSES improves quality of life and reduces postoperative anxiety and depression, helping patients to recover. At the same time, the short-term outcomes were comparable to CL.</p>

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Quality of life, anxiety and depression risks after natural orifice specimen extraction surgery and conventional laparoscopic surgery for colorectal cancer patients: a prospective two-centre case-matched study

  • 期刊论文

  • 发表日期：

    2026年3月2日

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  • Sergey Efetov,
  • Yu Cao,
  • Yuliuming Wang,
  • Denis Khlusov,
  • Albina Zubayraeva,
  • Songtao Yu,
  • Guiyu Wang

摘要

Background

Numerous studies have confirmed that the NOSES has significant short-term prognostic benefits in the treatment of CRC. However, there is still an obvious gap in the systematic assessment of the psychological status of patients in the perioperative period, such as anxiety and depression. Our study aims to compare the quality of life and psychological functions, as well as the short-term surgical outcomes in patients undergoing NOSES and conventional laparoscopic surgery.

Methods

This prospective study included patients diagnosed with CRC who underwent radical resection between January 2021 and August 2024 at Sechenov University and Harbin Medical University. Patients were segregated into NOSES group and CL group based on case-match method. Quality of life was assessed using the Short-Form 36 Health Survey (SF-36), Beck Depression Inventory (BDI) and Spielberger State-Trait Anxiety Inventory (STAI) preoperative, predischarge, postoperative 3 months and postoperative 6 months.

Results

A total of 92 patients (46 in the NOSES group and 46 in the CL group) were included. The NOSES group showed faster gastrointestinal recovery and subsequently shorter hospital stays than the CL group. Postoperative pain scores were significantly lower in the NOSES group on the first, third and fifth postoperative days. At three months postoperatively, role function, physical pain, vitality, emotional state and mental health were better in the NOSES group than in the CL group. In addition, patients in the NOSES group had better role function, physical pain, vitality, social function, emotional state and mental health than patients in the CL group. As for postoperative anxiety and depression, patients in the NOSES group were significantly better than patients in the CL group before discharge, three months after surgery and six months after surgery.

Conclusion

NOSES improves quality of life and reduces postoperative anxiety and depression, helping patients to recover. At the same time, the short-term outcomes were comparable to CL.