Scholarlink

Purpose <p>This study aimed to characterize bowel function, anorectal physiology, and health-related quality of life (HRQoL) in rectal cancer patients following low anterior resection (LAR), comparing three groups: a control group with late stoma closure (LSC) (&gt;&#xa0; 3 months), an early stoma closure group (ESC) (8–10 days), and an anastomotic leakage group (AL).</p> Methods <p>This cross-sectional study evaluated anorectal function using anorectal manometry. Bowel function and HRQoL were assessed using the low anterior resection syndrome (LARS) score and the EORTC QLQ-CR29 questionnaires.</p> Results <p>Of 124 eligible participants, 42 accepted participation. ESC and AL had significantly lower median (IQR) pressures in mmHg compared to LSC: rest: LSC: 54 (50–77), ESC: 35 (20–45), AL: 28 (22.5–33), <i>p</i> = 0.001, <i>p</i> &lt; 0.001; squeeze: LSC: 140 (95–168), ESC: 70 (46–95), AL: 71 (45–81.5), <i>p</i> = 0.010, <i>p</i> = 0.004; squeeze pressure increments: LSC: 72 (60–89), ESC: 36 (30–48) and AL: 38 (25.5–54), <i>p</i> = 0.003, <i>p</i> = 0.004. ESC showed higher but non-significant median (IQR) volumes in ml: first sensation: LSC: 30 (20–40), ESC: 40 (30–50), <i>p</i> = 0.153; urge: LSC: 55 (45–100), ESC: 90 (65–100) <i>p</i> = 0.269; max: LSC: 110 (80–180), ESC: 142 (105–179), <i>p</i> = 0.713. No differences in mean (95% CI) total LARS scores were detected: LSC: 26.5 (21.9–31.1), ESC: 29.5 (25.9–33.1), AL: 33.0 (28.0–38.0), <i>p</i> = 0.320, <i>p</i> = 0.051. Mean (95% CI) stool frequency was significantly higher in AL: 44.4 (32.1–56.8) compared to LSC: 29.4 (20.5–38.4), <i>p</i> = 0.041. No differences in HRQoL were detected between the groups (<i>p</i> = 0.681, <i>p</i> = 0.129).</p> Conclusion <p>No differences in anorectal function and HRQoL were detected between early and late reversal of diverting loop ileostomy.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Impact of timing of ileostomy reversal and anastomotic leakage on bowel function and health-related quality of life following rectal cancer surgery: a cross-sectional study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月12日

查看全文
  • Ditte Reitz Petersen,
  • Pia Møller Faaborg,
  • Issam Al-Najami,
  • Maja Mi Thygesen,
  • Anna Pilegaard Bjarnesen Mølstrøm,
  • Sören Möller,
  • Mark Bremholm Ellebæk

摘要

Purpose

This study aimed to characterize bowel function, anorectal physiology, and health-related quality of life (HRQoL) in rectal cancer patients following low anterior resection (LAR), comparing three groups: a control group with late stoma closure (LSC) (>  3 months), an early stoma closure group (ESC) (8–10 days), and an anastomotic leakage group (AL).

Methods

This cross-sectional study evaluated anorectal function using anorectal manometry. Bowel function and HRQoL were assessed using the low anterior resection syndrome (LARS) score and the EORTC QLQ-CR29 questionnaires.

Results

Of 124 eligible participants, 42 accepted participation. ESC and AL had significantly lower median (IQR) pressures in mmHg compared to LSC: rest: LSC: 54 (50–77), ESC: 35 (20–45), AL: 28 (22.5–33), p = 0.001, p < 0.001; squeeze: LSC: 140 (95–168), ESC: 70 (46–95), AL: 71 (45–81.5), p = 0.010, p = 0.004; squeeze pressure increments: LSC: 72 (60–89), ESC: 36 (30–48) and AL: 38 (25.5–54), p = 0.003, p = 0.004. ESC showed higher but non-significant median (IQR) volumes in ml: first sensation: LSC: 30 (20–40), ESC: 40 (30–50), p = 0.153; urge: LSC: 55 (45–100), ESC: 90 (65–100) p = 0.269; max: LSC: 110 (80–180), ESC: 142 (105–179), p = 0.713. No differences in mean (95% CI) total LARS scores were detected: LSC: 26.5 (21.9–31.1), ESC: 29.5 (25.9–33.1), AL: 33.0 (28.0–38.0), p = 0.320, p = 0.051. Mean (95% CI) stool frequency was significantly higher in AL: 44.4 (32.1–56.8) compared to LSC: 29.4 (20.5–38.4), p = 0.041. No differences in HRQoL were detected between the groups (p = 0.681, p = 0.129).

Conclusion

No differences in anorectal function and HRQoL were detected between early and late reversal of diverting loop ileostomy.