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Objective <p>To compare the long‐term safety and efficacy of endoscopic radiofrequency ablation (ERFA) versus endoscopic band ligation (EBL) in the treatment of gastroesophageal reflux disease (GERD).</p> Methods <p>A retrospective analysis was conducted on the clinical data of 139 patients who underwent endoscopic treatment for GERD. According to the treatment modality, patients were divided into an ERFA group (<i>n</i> = 50) and an EBL group (<i>n</i> = 89). Primary outcome measures included the DeMeester score, GerdQ score, symptom relief rate, and complication rate.</p> Results <p>No significant differences were found in baseline characteristics (all <i>P</i> &gt; 0.05). Key results include (1) Intraoperative blood loss was 1.04 ± 0.20&#xa0;mL (ERFA) vs. 1.10 ± 0.75&#xa0;mL (EBL). (2) Both groups showed reduced DeMeester scores: ERFA from 28.16 ± 20.01 to 6.77 ± 3.95 and EBL from 26.18 ± 13.39 to 6.26 ± 4.33 (both <i>P</i> &lt; 0.001). (3) GERD-Q scores improved: ERFA from 11.84 ± 2.92 to 3.58 ± 2.75 and EBL from 12.13 ± 2.70 to 3.54 ± 3.05 (both <i>P</i> &lt; 0.001). (4) Symptom relief was 48.0% (ERFA) vs. 58.4% (EBL). (5) Complications were low: 2 cases (4.0%) bleeding in ERFA; 3 cases (3.4%) bleeding; and 1 case (1.1%) perforation in EBL, with no significant difference between groups (<i>P</i> = 0.677). (6) Complete drug discontinuation rates were 72.0% (ERFA) and 73.0% (EBL). (7) Mean LES pressure was 15.15 ± 5.99&#xa0;mmHg (ERFA) vs. 14.81 ± 6.76&#xa0;mmHg (EBL).</p> Conclusion <p>Both ERFA and EBL are safe and efficacious treatments for GERD. Three‐year follow‐up data indicate comparable efficacy between the two approaches in symptom control.</p>

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Comparative safety and efficacy of endoscopic band ligation versus endoscopic radiofrequency ablation for gastroesophageal reflux disease

  • 期刊论文

  • 发表日期：

    2026年2月5日

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  • Wenjuan Wang,
  • Liya Luo,
  • Qing Shi,
  • Zhengqi Yang,
  • Canyu Zhan,
  • Hanlin Liu,
  • Hong Yang,
  • Suye Ran,
  • Min Wen,
  • Sha Zou,
  • Liju Liu,
  • Linya Huang,
  • Qi Liu,
  • Lingyu Song

摘要

Objective

To compare the long‐term safety and efficacy of endoscopic radiofrequency ablation (ERFA) versus endoscopic band ligation (EBL) in the treatment of gastroesophageal reflux disease (GERD).

Methods

A retrospective analysis was conducted on the clinical data of 139 patients who underwent endoscopic treatment for GERD. According to the treatment modality, patients were divided into an ERFA group (n = 50) and an EBL group (n = 89). Primary outcome measures included the DeMeester score, GerdQ score, symptom relief rate, and complication rate.

Results

No significant differences were found in baseline characteristics (all P > 0.05). Key results include (1) Intraoperative blood loss was 1.04 ± 0.20 mL (ERFA) vs. 1.10 ± 0.75 mL (EBL). (2) Both groups showed reduced DeMeester scores: ERFA from 28.16 ± 20.01 to 6.77 ± 3.95 and EBL from 26.18 ± 13.39 to 6.26 ± 4.33 (both P < 0.001). (3) GERD-Q scores improved: ERFA from 11.84 ± 2.92 to 3.58 ± 2.75 and EBL from 12.13 ± 2.70 to 3.54 ± 3.05 (both P < 0.001). (4) Symptom relief was 48.0% (ERFA) vs. 58.4% (EBL). (5) Complications were low: 2 cases (4.0%) bleeding in ERFA; 3 cases (3.4%) bleeding; and 1 case (1.1%) perforation in EBL, with no significant difference between groups (P = 0.677). (6) Complete drug discontinuation rates were 72.0% (ERFA) and 73.0% (EBL). (7) Mean LES pressure was 15.15 ± 5.99 mmHg (ERFA) vs. 14.81 ± 6.76 mmHg (EBL).

Conclusion

Both ERFA and EBL are safe and efficacious treatments for GERD. Three‐year follow‐up data indicate comparable efficacy between the two approaches in symptom control.