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Background and aims <p>This study aimed to evaluate the efficacy, safety, and factors influencing closure speed of the through-the-scope twin clip (TTS-TC) for endoscopic defect closure.</p> Methods <p>A retrospective observational study was conducted at a single center, involving patients who underwent endoscopic closure using the TTS-TC from December 2022 to December 2024.</p> Results <p>TTS-TC was successfully deployed in all 78 patients, yielding a complete closure rate of 98.7% (78/79 defects). The median defect area was 10.5 (6.3–15.8) cm<sup>2</sup>. Median procedure time was 15.0 (10.0–19.0) min, corresponding to a median closure speed of 0.73(0.45, 1.07) cm<sup>2</sup>/min. Univariate and multivariate analyses identified operator experience and defect area as independent factors of closure speed. Early complications included local peritonitis in 3.8% (3/78) and infection in 1.3% (1/78); delayed bleeding and long-term adverse events did not occur.</p> Conclusions <p>The TTS-TC emerges as a promising tool for the closure of diverse gastrointestinal defects, offering a new dimension in endoscopic management.</p> Graphical abstract <p></p>

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Through-the-scope twin clip for endoscopic closure of gastrointestinal defects: efficacy, safety, and factors influencing closure speed

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月29日

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  • Chenyang Li,
  • Chao Chen,
  • Fuxiu Huang,
  • Ningning Zhang,
  • Tao Wang,
  • Yan Xu,
  • Zhongrui Xu,
  • Hui Zhao,
  • Zhimin Liang,
  • Shuling Li,
  • Yujie Feng

摘要

Background and aims

This study aimed to evaluate the efficacy, safety, and factors influencing closure speed of the through-the-scope twin clip (TTS-TC) for endoscopic defect closure.

Methods

A retrospective observational study was conducted at a single center, involving patients who underwent endoscopic closure using the TTS-TC from December 2022 to December 2024.

Results

TTS-TC was successfully deployed in all 78 patients, yielding a complete closure rate of 98.7% (78/79 defects). The median defect area was 10.5 (6.3–15.8) cm2. Median procedure time was 15.0 (10.0–19.0) min, corresponding to a median closure speed of 0.73(0.45, 1.07) cm2/min. Univariate and multivariate analyses identified operator experience and defect area as independent factors of closure speed. Early complications included local peritonitis in 3.8% (3/78) and infection in 1.3% (1/78); delayed bleeding and long-term adverse events did not occur.

Conclusions

The TTS-TC emerges as a promising tool for the closure of diverse gastrointestinal defects, offering a new dimension in endoscopic management.

Graphical abstract