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Background <p>Endoscopic submucosal dissection (ESD) is widely used to treat superficial lesions of the esophagus. Post-ESD electrocoagulation syndrome (PEECS) is a commonly occurring adverse event, however, the efficacy of antibiotic prophylaxis in preventing PEECS remains unclear.</p> Aims <p>To evaluate the efficacy of antibiotic prophylaxis (AP) in reducing the incidence of PEECS in patients undergoing esophageal ESD.</p> Methods <p>This retrospective study included consecutive patients who underwent ESD for single esophageal lesions at The First Affiliated Hospital, School of Medicine, Zhejiang University (1/2022–12/2024). Propensity score (PS) matching was applied to compare outcomes between AP and non-AP groups. Outcomes included&#xa0;incidences of PEECS, fever, and chest pain, along with various laboratory parameters and the length of stay (LOS) in the hospital.</p> Results <p>After PS matching, 262 patients were analyzed. The incidence of PEECS was 26.7% in the AP group versus 30.5% in the non-AP group, but this was not significantly different (<i>P</i> = 0.494). Univariate analysis identified muscle layer injury as a potential risk factor for PEECS [OR 1.986, 95%CI 1.125–3.504, <i>P</i> = 0.018].</p> Conclusion <p>AP did not reduce PEECS incidence in patients undergoing esophageal ESD.</p> Graphical abstract <p></p>

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Antibiotic prophylaxis against electrocoagulation syndrome after esophageal endoscopic submucosal dissection: a single center retrospective study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月5日

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  • Yi-Ru Zhao,
  • Xue-Qun Zhang

摘要

Background

Endoscopic submucosal dissection (ESD) is widely used to treat superficial lesions of the esophagus. Post-ESD electrocoagulation syndrome (PEECS) is a commonly occurring adverse event, however, the efficacy of antibiotic prophylaxis in preventing PEECS remains unclear.

Aims

To evaluate the efficacy of antibiotic prophylaxis (AP) in reducing the incidence of PEECS in patients undergoing esophageal ESD.

Methods

This retrospective study included consecutive patients who underwent ESD for single esophageal lesions at The First Affiliated Hospital, School of Medicine, Zhejiang University (1/2022–12/2024). Propensity score (PS) matching was applied to compare outcomes between AP and non-AP groups. Outcomes included incidences of PEECS, fever, and chest pain, along with various laboratory parameters and the length of stay (LOS) in the hospital.

Results

After PS matching, 262 patients were analyzed. The incidence of PEECS was 26.7% in the AP group versus 30.5% in the non-AP group, but this was not significantly different (P = 0.494). Univariate analysis identified muscle layer injury as a potential risk factor for PEECS [OR 1.986, 95%CI 1.125–3.504, P = 0.018].

Conclusion

AP did not reduce PEECS incidence in patients undergoing esophageal ESD.

Graphical abstract