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Introduction <p>Roux-en-Y gastric bypass (RYGB) has been well-established as a metabolic surgical procedure; however, long-term follow-up data is limited. The purpose of this study is to evaluate long-term (&gt; 15 year) outcomes following RYGB.</p> Methods <p>A retrospective review of RYGB performed at a single COE from 2001–2008 was conducted. Primary outcomes were mean percent total body weight loss (TBWL) (using repeated measures regression), percent with diabetes (compared between insulin and non-insulin using chi-square test), post-RYGB.</p> Results <p>During the analysis period, there were 2045 patients that underwent RYGB. Ten years or more of follow-up was available for 68% of the patients (n = 1388) and 48% had &gt; 15 years of follow-up (n = 987). Preoperative mean age was 46 (18–72) and BMI (kg/m2) 47.9 (35–82.2). Maximum mean post-RYGB TBWL of 31.8% occurred at 18 months post-operatively. Mean TBWL stabilized at 23% at 10–20 years post-RYGB. Of the 677 patients with pre-operative diabetes, 10% were insulin-dependent post-RYGB. Diabetes remission rates were 54% at 3 years but decreased to 38% at 15 years. The rate of persistent diabetes post-RYGB was higher in pre-operative insulin-treated diabetes (p &lt; 0.0001).</p> Conclusion <p>Our study represents one of the largest studies of long-term follow data for patients undergoing RYGB. Our data demonstrates that RYGB is successful in providing sustained, long-term, weight loss and diabetes remission.</p>

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Roux-en-Y gastric bypass results in long-term durable weight loss and diabetes remission: a single center, > 15 year outcomes

  • 期刊论文

  • 发表日期：

    2025年11月26日

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  • Luis Pina,
  • Alvin Chang,
  • G. Craig Wood,
  • Joseph Nguyen-Lee,
  • Ryan Horsley,
  • Alexandra Falvo,
  • Mark Mahan,
  • Vladan Obradovic,
  • Anthony T. Petrick,
  • David M. Parker

摘要

Introduction

Roux-en-Y gastric bypass (RYGB) has been well-established as a metabolic surgical procedure; however, long-term follow-up data is limited. The purpose of this study is to evaluate long-term (> 15 year) outcomes following RYGB.

Methods

A retrospective review of RYGB performed at a single COE from 2001–2008 was conducted. Primary outcomes were mean percent total body weight loss (TBWL) (using repeated measures regression), percent with diabetes (compared between insulin and non-insulin using chi-square test), post-RYGB.

Results

During the analysis period, there were 2045 patients that underwent RYGB. Ten years or more of follow-up was available for 68% of the patients (n = 1388) and 48% had > 15 years of follow-up (n = 987). Preoperative mean age was 46 (18–72) and BMI (kg/m2) 47.9 (35–82.2). Maximum mean post-RYGB TBWL of 31.8% occurred at 18 months post-operatively. Mean TBWL stabilized at 23% at 10–20 years post-RYGB. Of the 677 patients with pre-operative diabetes, 10% were insulin-dependent post-RYGB. Diabetes remission rates were 54% at 3 years but decreased to 38% at 15 years. The rate of persistent diabetes post-RYGB was higher in pre-operative insulin-treated diabetes (p < 0.0001).

Conclusion

Our study represents one of the largest studies of long-term follow data for patients undergoing RYGB. Our data demonstrates that RYGB is successful in providing sustained, long-term, weight loss and diabetes remission.