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Background <p>Surgical resection is the cornerstone for early-stage non-small cell lung cancer (NSCLC), with lobectomy historically standard. Evolving techniques have spurred debate comparing lobectomy and segmentectomy. This study analyzed early postoperative patient-reported symptoms and functional status in patients with early NSCLC undergoing either procedure.</p> Methods <p>This observational cohort study included 248 patients (Lobectomy = 92, Segmentectomy = 156) with early-stage NSCLC (tumor diameter ≤ 2&#xa0;cm) who underwent uniport video-assisted thoracoscopic surgery (VATS), from December 2021 to December 2023. Patient-reported outcomes were collected using the Perioperative Symptom Assessment for Patients Undergoing Lung Surgery scale at preoperative day 1, daily from postoperative days 1–4, and weekly for postoperative weeks 1–4. We compared early postoperative symptom/functional impairment scores, recovery time from moderate-to-severe symptoms, and short-term clinical outcomes.</p> Results <p>Both groups exhibited comparable early postoperative symptoms and functional status. No significant differences were observed between the two groups in any of the 7 symptom items or the 2 function items (all <i>P</i> &gt; 0.05). The time to recovery from moderate-to-severe symptoms and functional impairment was also similar between the groups. Furthermore, there were no statistically significant differences in short-term clinical outcomes, including operative time, postoperative hospital stays, drainage time, discharge scores, or complication rates (all <i>P</i> &gt; 0.05).</p> Conclusion <p>For early-stage NSCLC (tumor diameter ≤ 2&#xa0;cm) undergoing uniport VATS, lobectomy and segmentectomy yield largely similar early postoperative symptom/functional burden, recovery times, and short-term outcomes. Considering external evidence on long-term oncology and function, segmentectomy is supported as a highly suitable option for this patient population.</p>

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Patient-reported outcomes after lobectomy vs. segmentectomy for early-stage non-small cell lung cancer

  • 期刊论文

  • 发表日期：

    2025年9月9日

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  • Qian Hong,
  • Yan Wang,
  • Fengyan Ma,
  • Yinyan Gao,
  • Guochao Zhang,
  • Hang Yi,
  • Juwei Mu

摘要

Background

Surgical resection is the cornerstone for early-stage non-small cell lung cancer (NSCLC), with lobectomy historically standard. Evolving techniques have spurred debate comparing lobectomy and segmentectomy. This study analyzed early postoperative patient-reported symptoms and functional status in patients with early NSCLC undergoing either procedure.

Methods

This observational cohort study included 248 patients (Lobectomy = 92, Segmentectomy = 156) with early-stage NSCLC (tumor diameter ≤ 2 cm) who underwent uniport video-assisted thoracoscopic surgery (VATS), from December 2021 to December 2023. Patient-reported outcomes were collected using the Perioperative Symptom Assessment for Patients Undergoing Lung Surgery scale at preoperative day 1, daily from postoperative days 1–4, and weekly for postoperative weeks 1–4. We compared early postoperative symptom/functional impairment scores, recovery time from moderate-to-severe symptoms, and short-term clinical outcomes.

Results

Both groups exhibited comparable early postoperative symptoms and functional status. No significant differences were observed between the two groups in any of the 7 symptom items or the 2 function items (all P > 0.05). The time to recovery from moderate-to-severe symptoms and functional impairment was also similar between the groups. Furthermore, there were no statistically significant differences in short-term clinical outcomes, including operative time, postoperative hospital stays, drainage time, discharge scores, or complication rates (all P > 0.05).

Conclusion

For early-stage NSCLC (tumor diameter ≤ 2 cm) undergoing uniport VATS, lobectomy and segmentectomy yield largely similar early postoperative symptom/functional burden, recovery times, and short-term outcomes. Considering external evidence on long-term oncology and function, segmentectomy is supported as a highly suitable option for this patient population.