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Background <p>Preoperative localization of colorectal cancer (CRC) is essential for accurate resection and treatment planning. However, colonoscopy-based tumor localization may lack optimal accuracy, potentially affecting surgical outcomes and patient management. This study aimed to evaluate the accuracy of colonoscopic localization of CRC and identify predictors of preoperative endoscopic localization errors.</p> Methods <p>This post hoc analysis utilized data from a prospective observational study conducted between June 2016 and June 2018. The accuracy of preoperative colonoscopic localization was compared with surgical localization, which is considered the gold standard. Endoscopic and surgical tumor locations were categorized into eight segments. Surgical localization was confirmed by the presence of visible tattoos during surgery and pathological examination of the resected specimens. Predictors of preoperative endoscopic localization errors were also analyzed.</p> Results <p>A total of 342 patients were included in this study. The accuracy of preoperative endoscopic localization compared with surgical localization was 79.2% overall (colon: 90.3%; rectum: 57.8%). Lesion location in the rectum was significantly associated with localization errors (<i>P</i> &lt; 0.001). Tumors limited to the colon, patient age ≥ 65&#xa0;years [odds ratio (OR) 12.0; 95% confidence interval (CI) 1.57–91.6; <i>P</i> = 0.0167], and an insertion time ≥ 10&#xa0;min (OR 3.13; 95% CI 1.23–7.92; <i>P</i> = 0.0163) were independently associated with localization errors.</p> Conclusion <p>Endoscopic CRC localization was accurate in approximately 80% of cases when compared with surgical localization. Patients aged ≥ 65&#xa0;years and those with insertion times ≥ 10&#xa0;min in the colon may be at increased risk of localization errors.</p> Clinical trial registration <p>This study protocol was registered in the University Hospital Medical Network Clinical Trials Registry (UMIN000021012).</p> Graphical abstract <p></p>

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Evaluating the accuracy of preoperative endoscopic localization for colorectal cancer: post hoc analysis of a prospective study

  • 期刊论文

  • 发表日期：

    2025年7月2日

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  • Taishi Okumura,
  • Kenichiro Imai,
  • Kinichi Hotta,
  • Sayo Ito,
  • Yoshihiro Kishida,
  • Kazunori Takada,
  • Kohei Shigeta,
  • Noboru Kawata,
  • Masao Yoshida,
  • Yoichi Yamamoto,
  • Hirotoshi Ishiwatari,
  • Junya Sato,
  • Hiroyuki Matsubayashi,
  • Tetsushi Ishiguro,
  • Shoichi Manabe,
  • Yusuke Yamaoka,
  • Hiroyasu Kagawa,
  • Akio Shiomi,
  • Hiroyuki Ono

摘要

Background

Preoperative localization of colorectal cancer (CRC) is essential for accurate resection and treatment planning. However, colonoscopy-based tumor localization may lack optimal accuracy, potentially affecting surgical outcomes and patient management. This study aimed to evaluate the accuracy of colonoscopic localization of CRC and identify predictors of preoperative endoscopic localization errors.

Methods

This post hoc analysis utilized data from a prospective observational study conducted between June 2016 and June 2018. The accuracy of preoperative colonoscopic localization was compared with surgical localization, which is considered the gold standard. Endoscopic and surgical tumor locations were categorized into eight segments. Surgical localization was confirmed by the presence of visible tattoos during surgery and pathological examination of the resected specimens. Predictors of preoperative endoscopic localization errors were also analyzed.

Results

A total of 342 patients were included in this study. The accuracy of preoperative endoscopic localization compared with surgical localization was 79.2% overall (colon: 90.3%; rectum: 57.8%). Lesion location in the rectum was significantly associated with localization errors (P < 0.001). Tumors limited to the colon, patient age ≥ 65 years [odds ratio (OR) 12.0; 95% confidence interval (CI) 1.57–91.6; P = 0.0167], and an insertion time ≥ 10 min (OR 3.13; 95% CI 1.23–7.92; P = 0.0163) were independently associated with localization errors.

Conclusion

Endoscopic CRC localization was accurate in approximately 80% of cases when compared with surgical localization. Patients aged ≥ 65 years and those with insertion times ≥ 10 min in the colon may be at increased risk of localization errors.

Clinical trial registration

This study protocol was registered in the University Hospital Medical Network Clinical Trials Registry (UMIN000021012).

Graphical abstract