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Background <p>Gastro-Jejunal anastomotic ulcer is a late complication of bariatric surgery, typically responsive to high-dose proton pump inhibitors (PPI). However, persistent ulcers may require surgery. Endoscopic suturing of a jejunal flap has recently shown promise. This study evaluates its implementation in our practice.</p> Methods <p>We retrospectively analyzed 11 patients with refractory marginal ulcers (≥ 10mm) unresponsive to at least two months of high-dose PPI. In cases with a narrow anastomosis, a self-expandable metallic stent was added. Clinical success was defined as ulcer healing on endoscopy at 8 weeks, while failure included persistent ulcer, perforation, or need for surgery.</p> Results <p>Seven patients had undergone Roux-en-Y gastric bypass (RYGB) and four had one-anastomosis gastric bypass (OAGB). Ulcers were diagnosed on average 33 months post surgery. All patients were H. pylori-negative and denied alcohol/NSAID use; four were active smokers. Patients had been on chronic PPI therapy for an average of 25 months. Jejunal flap suturing was performed in 10 patients, with three also receiving a stent. One patient underwent stent placement alone due to stricture to relief obstructive symptoms. The technical success rate was 90.9%, but clinical success was 45%, with four patients requiring surgery. Notably, all OAGB patients had endoscopic failure, while 5 of 7 RYGB patients had ulcer healing.</p> Conclusion <p>Jejunal flap suturing showed moderate success in treating marginal ulcers, with a good safety profile. Larger studies are needed to corroborate these findings, especially in OAGB patients.</p> Graphical abstract <p></p>

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Endoscopic jejunal flap suturing for the treatment of refractory marginal ulcers—a case series

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月7日

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  • Tali Bar-On,
  • Relly Reicher,
  • Nathan Aviv Cohen,
  • Shai Eldar,
  • Danit Dayan,
  • Adam Abu-Abeid,
  • Sigal Fishman,
  • Mati Shnell

摘要

Background

Gastro-Jejunal anastomotic ulcer is a late complication of bariatric surgery, typically responsive to high-dose proton pump inhibitors (PPI). However, persistent ulcers may require surgery. Endoscopic suturing of a jejunal flap has recently shown promise. This study evaluates its implementation in our practice.

Methods

We retrospectively analyzed 11 patients with refractory marginal ulcers (≥ 10mm) unresponsive to at least two months of high-dose PPI. In cases with a narrow anastomosis, a self-expandable metallic stent was added. Clinical success was defined as ulcer healing on endoscopy at 8 weeks, while failure included persistent ulcer, perforation, or need for surgery.

Results

Seven patients had undergone Roux-en-Y gastric bypass (RYGB) and four had one-anastomosis gastric bypass (OAGB). Ulcers were diagnosed on average 33 months post surgery. All patients were H. pylori-negative and denied alcohol/NSAID use; four were active smokers. Patients had been on chronic PPI therapy for an average of 25 months. Jejunal flap suturing was performed in 10 patients, with three also receiving a stent. One patient underwent stent placement alone due to stricture to relief obstructive symptoms. The technical success rate was 90.9%, but clinical success was 45%, with four patients requiring surgery. Notably, all OAGB patients had endoscopic failure, while 5 of 7 RYGB patients had ulcer healing.

Conclusion

Jejunal flap suturing showed moderate success in treating marginal ulcers, with a good safety profile. Larger studies are needed to corroborate these findings, especially in OAGB patients.

Graphical abstract