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Background <p>The optimal management of gastrointestinal stromal tumor (GIST) ≤ 2&#xa0;cm in diameter remains debated. This study aimed to compare long-term survival outcomes between patients with small GIST undergoing endoscopic treatment (ET) and those treated with surgical resection (SR).</p> Methods <p>Between 2000 and 2021, patients with small GIST were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was employed to minimize selection bias in the comparison process. Kaplan–Meier analysis and multivariate Cox proportional hazards models were applied to evaluate the effects of demographic and clinical characteristics on overall survival (OS) and cancer-specific survival (CSS).</p> Results <p>A total of 1400 patients with small GIST were included, comprising 470 (33.57%) undergoing ET and 930 (66.43%) receiving SR. The 5-year OS and CSS rates were compared between the ET and SR groups both before and after PSM. Before PSM, the 5-year OS rates were 75.28% vs. 83.96% (<i>P</i> = 0.878), and CSS rates were 94.38% vs. 95.09% (<i>P</i> = 0.284). After PSM, the corresponding rates were 85.81% vs. 86.45% (<i>P</i> = 0.393) for OS and 96.77% vs. 95.48% (<i>P</i> = 0.075) for CSS. Multivariable analysis adjusting for covariates demonstrated comparable risks of OS (HR = 0.96, 95% CI 0.74–1.24, <i>P</i> = 0.737) and CSS (HR = 1.26, 95% CI 0.72–2.20, <i>P</i> = 0.426) between the two treatment groups. No significant differences were observed between the groups after PSM.</p> Conclusions <p>Our findings demonstrate comparable long-term OS and CSS outcomes between endoscopic and surgical treatment groups in patients with GIST ≤ 2&#xa0;cm in diameter.</p>

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Long-term outcomes of endoscopic treatment versus surgical resection for 0–2 cm gastrointestinal stromal tumor: A SEER database study

  • 期刊论文

  • 发表日期：

    2025年5月14日

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  • Siyu Tan,
  • Wenjing Yang,
  • Guowang Yang

摘要

Background

The optimal management of gastrointestinal stromal tumor (GIST) ≤ 2 cm in diameter remains debated. This study aimed to compare long-term survival outcomes between patients with small GIST undergoing endoscopic treatment (ET) and those treated with surgical resection (SR).

Methods

Between 2000 and 2021, patients with small GIST were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was employed to minimize selection bias in the comparison process. Kaplan–Meier analysis and multivariate Cox proportional hazards models were applied to evaluate the effects of demographic and clinical characteristics on overall survival (OS) and cancer-specific survival (CSS).

Results

A total of 1400 patients with small GIST were included, comprising 470 (33.57%) undergoing ET and 930 (66.43%) receiving SR. The 5-year OS and CSS rates were compared between the ET and SR groups both before and after PSM. Before PSM, the 5-year OS rates were 75.28% vs. 83.96% (P = 0.878), and CSS rates were 94.38% vs. 95.09% (P = 0.284). After PSM, the corresponding rates were 85.81% vs. 86.45% (P = 0.393) for OS and 96.77% vs. 95.48% (P = 0.075) for CSS. Multivariable analysis adjusting for covariates demonstrated comparable risks of OS (HR = 0.96, 95% CI 0.74–1.24, P = 0.737) and CSS (HR = 1.26, 95% CI 0.72–2.20, P = 0.426) between the two treatment groups. No significant differences were observed between the groups after PSM.

Conclusions

Our findings demonstrate comparable long-term OS and CSS outcomes between endoscopic and surgical treatment groups in patients with GIST ≤ 2 cm in diameter.