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Purpose <p>This systematic review and meta-analysis examined the comparative efficacy and safety of radioactive stents versus normal metal stents for the management of malignant biliary obstruction (MBO).</p> Methods <p>A comprehensive search of databases including PubMed, the Cochrane Library, and Embase was conducted to identify pertinent studies up to June 2024. The primary focus of this meta-analysis is on stent patency, postoperative survival, and the incidence of complications.</p> Results <p>The meta-analysis revealed that there was no statistically significant difference in the occurrence of complications, such as bleeding (<i>p</i> = 0.32), cholangitis (<i>P</i> = 0.19), pancreatitis (<i>P</i> = 0.43), and cholecystitis (<i>P</i> = 0.99), between the two types of stents. However, the radioactive stent demonstrated a significant improvement in both stent patency time (HR = 0.60, 95% CI 0.50–0.73; <i>P</i> &lt; 0.001) and patient survival time (HR = 0.63, 95% CI 0.53–0.74, <i>P</i> &lt; 0.001).</p> Conclusion <p>The results indicate that radioactive stents could present a more effective option compared to traditional stents for palliative management of malignant biliary obstruction, resulting in prolonged stent patency and potentially enhancing survival rates.</p>

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Radioactive stent versus normal stent insertion for inoperable malignant biliary obstruction: a systematic review and meta-analysis

  • 期刊论文

  • 发表日期：

    2025年3月6日

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  • Xiang Chen,
  • Jiaxing Li,
  • Wenwu Wan,
  • Hao Zhang,
  • Ding Xiong

摘要

Purpose

This systematic review and meta-analysis examined the comparative efficacy and safety of radioactive stents versus normal metal stents for the management of malignant biliary obstruction (MBO).

Methods

A comprehensive search of databases including PubMed, the Cochrane Library, and Embase was conducted to identify pertinent studies up to June 2024. The primary focus of this meta-analysis is on stent patency, postoperative survival, and the incidence of complications.

Results

The meta-analysis revealed that there was no statistically significant difference in the occurrence of complications, such as bleeding (p = 0.32), cholangitis (P = 0.19), pancreatitis (P = 0.43), and cholecystitis (P = 0.99), between the two types of stents. However, the radioactive stent demonstrated a significant improvement in both stent patency time (HR = 0.60, 95% CI 0.50–0.73; P < 0.001) and patient survival time (HR = 0.63, 95% CI 0.53–0.74, P < 0.001).

Conclusion

The results indicate that radioactive stents could present a more effective option compared to traditional stents for palliative management of malignant biliary obstruction, resulting in prolonged stent patency and potentially enhancing survival rates.