Complications after Heller myotomy in children: a national multicenter study on the impact of prior endoscopic dilatation and identification of risk factors

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发表日期：

2024年5月20日

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Louise Montalva,
Elie Farha,
Erik Hervieux,
Liza Ali,
Véronique Rousseau,
Françoise Schmitt,
Audrey Guinot,
Nizar Sassi,
Céline Grosos,
Alexis P. Arnaud,
Aurélien Scalabre,
Remi Dubois,
Arnaud Bonnard

摘要

Background

Although esophageal achalasia has been historically treated by Heller myotomy, endoscopic esophageal dilatations are nowadays often the first-line treatment in children. The aim was to assess whether performing an endoscopic dilatation before a Heller myotomy is associated with higher risks of esophageal perforation in children.

Methods

A retrospective multicentric study was performed, including children that underwent a Heller myotomy (2000–2022, 10 centers). Two groups were compared based on the history of previous dilatation before myotomy.

Outcomes esophageal perforation (intra-operative or secondary) and post-operative complications requiring surgery (Clavien-Dindo III).

Statistics Comparisons using contingency tables or Kruskal–Wallis when appropriate. Statistical significance: p-value < 0.05.

Results

A Heller myotomy was performed in 77 children (median age: 11.8 years), with prior endoscopic dilatation in 53% (n = 41). A laparoscopic approach was used in 90%, with associated fundoplication in 95%. Esophageal perforation occurred in 19% of children (n = 15), including 12 patients with intra-operative mucosal tear and 3 with post-operative complications related to an unnoticed esophageal perforation. Previous endoscopic dilatation did not increase the risk of esophageal perforation (22% vs 17%, OR: 1.4, 95%CI: 0.43–4.69). Post-operative complications occurred in 8% (n = 6), with similar rates regardless of prior endoscopic dilatation. Intra-operative mucosal tear was the only risk factor for post-operative complications, increasing the risk of complications from 5 to 25% (OR: 6.89, 95%CI: 1.38–31.87).

Conclusions

Prior endoscopic dilatations did not increase the risk of esophageal perforation or postoperative complications of Heller myotomy in this cohort of children with achalasia. Mucosal tear was identified as a risk factor for post-operative complications.

Graphical abstract