In this paper we prove that the \(\ell _0\) isoperimetric coefficient for axis-aligned cubes, \(\psi _{\mathcal {C}}\) , is \(\Theta (n^{-1/2})\) and that the isoperimetric coefficient for any measurable body K, \(\psi _K\) , is of order \(O(n^{-1/2})\) . As a corollary we deduce that axis-aligned cubes essentially “maximize” the \(\ell _0\) isoperimetric coefficient: There exists a positive constant \(q > 0\) such that \(\psi _K \le q \cdot \psi _{\mathcal {C}}\) , whenever \(\mathcal {C}\) is an axis-aligned cube and K is any measurable set. Lastly, we give immediate applications of our results to the mixing time of Coordinate-Hit-and-Run for sampling points uniformly from convex bodies.