Scholarlink

<p>Hearing loss is a prevalent sensory condition that affects the ability to perceive sounds. Hair cells play a vital role in hearing by converting mechanical sound vibrations into electrical signals that are transmitted to the brain. In humans, if damaged, these specialized sensory cells do not regenerate, leading to reduced sensitivity to sound, difficulty understanding speech, and deafness. The incidence of hearing loss increases with age, but it can also occur earlier due to genetic predisposition or environmental factors such as exposure to noise or ototoxic medications. Epigenetic mechanisms play a significant role in age-related hearing loss (ARHL) by regulating gene expression without changing the underlying DNA sequence. Aberrant DNA methylation patterns have been linked to ARHL. In this study, by performing an epigenome-wide association study in a cohort of 30 ARHL patients, we found a correlation between a specific CpG site methylation level proximal to the <i>TNFRSF25</i> gene, with an impaired hearing threshold. Interestingly, <i>Tnfrsf25</i> absence in mice cause ARHL, severe hair cell depletion, and degeneration of nerve fibers. Taking together these results suggests a crucial role of <i>Tnfrsf25</i> expression in hearing maintenance.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The involvement of TNFRSF25 in age-related hearing loss

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月26日

查看全文
  • Marie Valerie Roche,
  • Pei-Ciao Tang,
  • Denise Yan,
  • Michelle Rose De Marchena,
  • Maria Camila Robayo,
  • Clemer Abad,
  • Yan Guo,
  • Feng Gong,
  • Katherina Walz,
  • Xue Zhong Liu

摘要

Hearing loss is a prevalent sensory condition that affects the ability to perceive sounds. Hair cells play a vital role in hearing by converting mechanical sound vibrations into electrical signals that are transmitted to the brain. In humans, if damaged, these specialized sensory cells do not regenerate, leading to reduced sensitivity to sound, difficulty understanding speech, and deafness. The incidence of hearing loss increases with age, but it can also occur earlier due to genetic predisposition or environmental factors such as exposure to noise or ototoxic medications. Epigenetic mechanisms play a significant role in age-related hearing loss (ARHL) by regulating gene expression without changing the underlying DNA sequence. Aberrant DNA methylation patterns have been linked to ARHL. In this study, by performing an epigenome-wide association study in a cohort of 30 ARHL patients, we found a correlation between a specific CpG site methylation level proximal to the TNFRSF25 gene, with an impaired hearing threshold. Interestingly, Tnfrsf25 absence in mice cause ARHL, severe hair cell depletion, and degeneration of nerve fibers. Taking together these results suggests a crucial role of Tnfrsf25 expression in hearing maintenance.