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<p>The enzymatic breakdown of organophosphate (OP) nerve agents marks a pivotal advancement in both bioremediation and biodefense. This review explores the genetic diversity and evolutionary lineage of phosphotriesterase-related proteins across multiple species, with a particular focus on the Php domain, key to substrate recognition and hydrolysis. The study underscores the functional importance of Php-containing enzymes in neutralizing G-series nerve agents, highlighting their promise for environmental detoxification and defense applications. By laying the groundwork for enzyme-based OP degradation strategies, this work emphasizes the need for continued research and optimization of these enzymes and their microbial hosts to support sustainable remediation efforts.</p>

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Role of Php domain and related enzymes in the enzymatic degradation of G-series nerve agents

  • 期刊论文

  • 发表日期：

    2025年8月21日

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  • Divya Ramamoorthy,
  • Rupa Iyer

摘要

The enzymatic breakdown of organophosphate (OP) nerve agents marks a pivotal advancement in both bioremediation and biodefense. This review explores the genetic diversity and evolutionary lineage of phosphotriesterase-related proteins across multiple species, with a particular focus on the Php domain, key to substrate recognition and hydrolysis. The study underscores the functional importance of Php-containing enzymes in neutralizing G-series nerve agents, highlighting their promise for environmental detoxification and defense applications. By laying the groundwork for enzyme-based OP degradation strategies, this work emphasizes the need for continued research and optimization of these enzymes and their microbial hosts to support sustainable remediation efforts.