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Purpose <p>To report the efficacy and safety of enfortumab vedotin combined with toripalimab as neoadjuvant therapy in an elderly patient with muscle-invasive bladder cancer (MIBC) who sought bladder preservation.</p> Methods <p>An 83-year-old male presented with painless gross hematuria. Imaging revealed a 44&#xa0;mm × 39&#xa0;mm × 60&#xa0;mm bladder mass, and biopsy confirmed high-grade invasive papillary urothelial carcinoma (cT2NxM0). After informed consent, the patient received three cycles of neoadjuvant therapy combining enfortumab vedotin (60&#xa0;mg on days 1 and 8) with toripalimab (240&#xa0;mg on days 1 and 8) in 21-day cycles.</p> Results <p>Treatment-related adverse events included hyperglycemia and rash, both managed conservatively without treatment interruption. Post-treatment MRI demonstrated marked tumor reduction, showing only bladder wall thickening. Subsequent transurethral resection of bladder tumor (TURBT) revealed chronic mucosal inflammation with histiocyte aggregation and focal cystic cystitis, with no residual carcinoma identified in the resected specimen, indicating a favorable pathological response.</p> Conclusion <p>In this carefully selected elderly MIBC patient, neoadjuvant enfortumab vedotin combined with toripalimab was well tolerated and associated with marked tumor regression and a favorable pathological response on post-treatment TURBT. Bladder preservation was attempted, illustrating the feasibility of this regimen and generating a hypothesis for future investigation.</p>

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Favorable pathological response with enfortumab vedotin plus toripalimab as neoadjuvant therapy for HER2-negative muscle-invasive bladder cancer: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月17日

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  • Xi Zhang,
  • ErChang Shen,
  • Chao Cheng,
  • Rui Meng,
  • Chao Liu,
  • Qiang Shao

摘要

Purpose

To report the efficacy and safety of enfortumab vedotin combined with toripalimab as neoadjuvant therapy in an elderly patient with muscle-invasive bladder cancer (MIBC) who sought bladder preservation.

Methods

An 83-year-old male presented with painless gross hematuria. Imaging revealed a 44 mm × 39 mm × 60 mm bladder mass, and biopsy confirmed high-grade invasive papillary urothelial carcinoma (cT2NxM0). After informed consent, the patient received three cycles of neoadjuvant therapy combining enfortumab vedotin (60 mg on days 1 and 8) with toripalimab (240 mg on days 1 and 8) in 21-day cycles.

Results

Treatment-related adverse events included hyperglycemia and rash, both managed conservatively without treatment interruption. Post-treatment MRI demonstrated marked tumor reduction, showing only bladder wall thickening. Subsequent transurethral resection of bladder tumor (TURBT) revealed chronic mucosal inflammation with histiocyte aggregation and focal cystic cystitis, with no residual carcinoma identified in the resected specimen, indicating a favorable pathological response.

Conclusion

In this carefully selected elderly MIBC patient, neoadjuvant enfortumab vedotin combined with toripalimab was well tolerated and associated with marked tumor regression and a favorable pathological response on post-treatment TURBT. Bladder preservation was attempted, illustrating the feasibility of this regimen and generating a hypothesis for future investigation.