<p>Endometrial cancer is a significant threat to the health of women worldwide. Extracellular vesicles are essential for the proliferation, migration, and invasion of cancer cells, whereas tumour-associated macrophages (TAMs) are key regulators of cancer development. The interaction between macrophages and extracellular vesicles is also important in endometrial cancer. Extracellular vesicles from endometrial cancer cells can promote the polarization of macrophages towards an M2-like phenotype, and those from macrophages can also decrease the sensitivity of endometrial cancer cells to radiation. This paper presents a review of the various roles of extracellular vesicles in endometrial cancer and their potential as biomarkers and therapeutic targets. Research progress on the communication between endometrial cancer cells and tumour-associated macrophages mediated by extracellular vesicles is reviewed as well.</p>