Synchronous versus metachronous spinal metastasis: a comparative study of survival outcomes following neurosurgical treatment

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2024年3月19日

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Mohammed Banat,
Anna-Laura Potthoff,
Motaz Hamed,
Valeri Borger,
Jasmin E. Scorzin,
Tim Lampmann,
Harun Asoglu,
Logman Khalafov,
Frederic C. Schmeel,
Daniel Paech,
Alexander Radbruch,
Louisa Nitsch,
Johannes Weller,
Ulrich Herrlinger,
Marieta Toma,
Gerrit H. Gielen,
Hartmut Vatter,
Matthias Schneider

摘要

Purpose

Patients with spinal metastases (SM) from solid neoplasms typically exhibit progression to an advanced cancer stage. Such metastases can either develop concurrently with an existing cancer diagnosis (termed metachronous SM) or emerge as the initial indication of an undiagnosed malignancy (referred to as synchronous SM). The present study investigates the prognostic implications of synchronous compared to metachronous SM following surgical resection.

Methods

From 2015 to 2020, a total of 211 individuals underwent surgical intervention for SM at our neuro-oncology facility. We conducted a survival analysis starting from the date of the neurosurgical procedure, comparing those diagnosed with synchronous SM against those with metachronous SM.

Results

The predominant primary tumor types included lung cancer (23%), prostate cancer (21%), and breast cancer (11.3%). Of the participants, 97 (46%) had synchronous SM, while 114 (54%) had metachronous SM. The median overall survival post-surgery for those with synchronous SM was 13.5 months (95% confidence interval (CI) 6.1–15.8) compared to 13 months (95% CI 7.7–14.2) for those with metachronous SM (p = 0.74).

Conclusions

Our findings suggest that the timing of SM diagnosis (synchronous versus metachronous) does not significantly affect survival outcomes following neurosurgical treatment for SM. These results support the consideration of neurosurgical procedures regardless of the temporal pattern of SM manifestation.