Pediatric traumatic brain injury (TBI) is a major public health concern requiring coordinated management within an organized trauma system. This study aimed to analyze the epidemiology and temporal trends of pediatric TBI in Lombardy (Italy) and to evaluate centralization patterns within the regional hub-and-spoke trauma network. We conducted a retrospective, population-based study using regional administrative healthcare databases. All healthcare episodes of children (< 18 years) with a diagnosis of TBI residing in Lombardy (Italy) who presented to emergency departments (EDs) between January 2012 and December 2022 were included. ED visits, hospital admissions, and intensive care unit (ICU) admissions were analyzed. Temporal trends in ED visits, hospital admissions, and ICU admissions were evaluated using standardized rates and regression models. Centralization was assessed through temporal changes in ICU referral patterns within the regional trauma network. A total of 143,961 ED visits and 14,223 hospital admissions for pediatric TBI were recorded. ED visit rates declined significantly over time (adjusted annual reduction ≈1%), while hospital admission rates also declined significantly (adjusted annual reduction ≈4%). In contrast, no significant temporal trend was observed for ICU admissions after multivariable adjustment. The proportion of ICU admissions managed at the designated regional referral center increased progressively over time. Conclusion: This population-based study identified declining recorded ED visits and hospital admissions for pediatric TBI, alongside increasing concentration of ICU-managed pediatric TBI cases at a high-volume referral center within a structured trauma system. These findings are consistent with the evolution of the regional hub-and-spoke trauma system. <Table Float="No" ID="Taba"> <tgroup cols="2"> <colspec align="left" colname="c1" colnum="1" /> <colspec align="left" colname="c2" colnum="2" /> <tbody> <row> <entry nameend="c2" namest="c1"> What is Known: • Pediatric traumatic brain injury (TBI) is a major cause of emergency department visits and trauma-related hospitalizations in children. • Specialized pediatric trauma systems and referral to high-volume centers are recommended for severe pediatric TBI management. </entry> </row> <row> <entry nameend="c2" namest="c1"> What is New: • This population-based study provides an 11-year assessment of pediatric TBI epidemiology and temporal trends across an entire regional trauma network. • Over time, pediatric TBI cases requiring intensive care were increasingly managed at the regional referral center, consistent with the evolution of a regional hub-and-spoke trauma system. </entry> </row> </tbody> </tgroup> </Table>

Epidemiology and centralization of pediatric traumatic brain injury care in Lombardy, Italy: An 11-year regional population-based study

期刊论文
发表日期：

2026年8月1日

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Floriana Ferrari,
Rita Campi,
Stefano Finazzi,
Giovanni Tricella,
Ida Fortino,
Nicole Parati,
Ezio Bonanomi,
Daniele Bonacina,
Antonio Clavenna

摘要

Pediatric traumatic brain injury (TBI) is a major public health concern requiring coordinated management within an organized trauma system. This study aimed to analyze the epidemiology and temporal trends of pediatric TBI in Lombardy (Italy) and to evaluate centralization patterns within the regional hub-and-spoke trauma network. We conducted a retrospective, population-based study using regional administrative healthcare databases. All healthcare episodes of children (< 18 years) with a diagnosis of TBI residing in Lombardy (Italy) who presented to emergency departments (EDs) between January 2012 and December 2022 were included. ED visits, hospital admissions, and intensive care unit (ICU) admissions were analyzed. Temporal trends in ED visits, hospital admissions, and ICU admissions were evaluated using standardized rates and regression models. Centralization was assessed through temporal changes in ICU referral patterns within the regional trauma network. A total of 143,961 ED visits and 14,223 hospital admissions for pediatric TBI were recorded. ED visit rates declined significantly over time (adjusted annual reduction ≈1%), while hospital admission rates also declined significantly (adjusted annual reduction ≈4%). In contrast, no significant temporal trend was observed for ICU admissions after multivariable adjustment. The proportion of ICU admissions managed at the designated regional referral center increased progressively over time. Conclusion: This population-based study identified declining recorded ED visits and hospital admissions for pediatric TBI, alongside increasing concentration of ICU-managed pediatric TBI cases at a high-volume referral center within a structured trauma system. These findings are consistent with the evolution of the regional hub-and-spoke trauma system.

What is Known:

• Pediatric traumatic brain injury (TBI) is a major cause of emergency department visits and trauma-related hospitalizations in children.

• Specialized pediatric trauma systems and referral to high-volume centers are recommended for severe pediatric TBI management.

What is New:

• This population-based study provides an 11-year assessment of pediatric TBI epidemiology and temporal trends across an entire regional trauma network.

• Over time, pediatric TBI cases requiring intensive care were increasingly managed at the regional referral center, consistent with the evolution of a regional hub-and-spoke trauma system.