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<p>Children with new-onset type 1 diabetes (T1DM) may experience some growth delay. To compare growth trajectories assessed by z-height and z-BMI over a 3-year follow-up period between children with new-onset T1DM and a control group without T1DM across multiple Latin American centers. A retrospective analysis of medical records was conducted over 3&#xa0;years (2021–2024) in children with new-onset T1DM and their controls from ten Latin American centers, including age, sex, and anthropometric measures. A mixed-effects model was used to analyze z-height and z-BMI over three years. A total of 534 participants were included, comprising 245 children with T1DM (51.4% female; mean age, 8.8&#xa0;years) and 289 controls (45.7% female; mean age, 8.1&#xa0;years). The mean z-BMI in children with T1DM compared to controls was at years 0 (− 0.12 vs. 0.54), 1 (0.36 vs. 0.63), 2 (0.32 vs. 0.55), and 3 (0.34 vs. 0.47). Children with T1DM had a significantly lower z-BMI than controls, with mean differences of − 0.71, − 0.33, and − 0.28 in years 0, 1, and 2, respectively. However, by year 3, the mean difference (− 0.18) was no longer significant. z-height in children with T1DM vs. controls was at years 1 (− 0.08 vs. − 0.09), 2 (− 0.24 vs. − 0.12), and 3 (− 0.35 vs. − 0.12). z-height remained stable in controls but declined in the T1DM group, reaching a mean difference of − 0.25 (<i>p</i> &lt; 0.01) by year 3.</p><p><i>Conclusions</i>: This study demonstrated that despite treatment and equalization of z-BMI, children with T1DM in Latin America experience a progressive decline in linear growth.<Table Float="No" ID="Taba"> <tgroup cols="2"> <colspec align="left" colname="c1" colnum="1" /> <colspec align="left" colname="c2" colnum="2" /> <tbody> <row> <entry nameend="c2" namest="c1"> <p><b>What is Known:</b></p> <p>•&#xa0;<i>Children with type 1 diabetes may experience impaired linear growth and lower BMI at disease onset, particularly in association with poor metabolic control.</i></p> </entry> </row> <row> <entry nameend="c2" namest="c1"> <p><b>What is New:</b></p> <p>• <i>This multicenter Latin American study showed that although BMI normalized after treatment initiation, children with type 1 diabetes exhibited a progressive decline in height z-scores over the first three years after diagnosis compared with healthy controls.</i></p> </entry> </row> </tbody> </tgroup> </Table></p>

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Contrasting BMI and height z-score trajectories in children with new-onset T1DM: a case–control study across Latin American Centers

  • 期刊论文

  • 发表日期：

    2026年5月21日

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  • Valeria Hirschler,
  • Claudia Molinari,
  • Claudio Gonzalez,
  • Daniel R. Witte,
  • Angela Figueroa Sobrero,
  • Ernesto Bogado,
  • Victoria Femenia,
  • Maria L. Major,
  • Amanda J. Benitez,
  • Carlos M. Del Aguila Villar,
  • Oswaldo Núñez Almache,
  • Andrea Escalante Marassi,
  • Sandra Mazzetti,
  • Eduardo Rossi,
  • Laura Pardo,
  • Edit Scaiola,
  • Patricia Bocco,
  • Maria Eugenia Andres,
  • Maria Laura Arzamendia

摘要

Children with new-onset type 1 diabetes (T1DM) may experience some growth delay. To compare growth trajectories assessed by z-height and z-BMI over a 3-year follow-up period between children with new-onset T1DM and a control group without T1DM across multiple Latin American centers. A retrospective analysis of medical records was conducted over 3 years (2021–2024) in children with new-onset T1DM and their controls from ten Latin American centers, including age, sex, and anthropometric measures. A mixed-effects model was used to analyze z-height and z-BMI over three years. A total of 534 participants were included, comprising 245 children with T1DM (51.4% female; mean age, 8.8 years) and 289 controls (45.7% female; mean age, 8.1 years). The mean z-BMI in children with T1DM compared to controls was at years 0 (− 0.12 vs. 0.54), 1 (0.36 vs. 0.63), 2 (0.32 vs. 0.55), and 3 (0.34 vs. 0.47). Children with T1DM had a significantly lower z-BMI than controls, with mean differences of − 0.71, − 0.33, and − 0.28 in years 0, 1, and 2, respectively. However, by year 3, the mean difference (− 0.18) was no longer significant. z-height in children with T1DM vs. controls was at years 1 (− 0.08 vs. − 0.09), 2 (− 0.24 vs. − 0.12), and 3 (− 0.35 vs. − 0.12). z-height remained stable in controls but declined in the T1DM group, reaching a mean difference of − 0.25 (p < 0.01) by year 3.

Conclusions: This study demonstrated that despite treatment and equalization of z-BMI, children with T1DM in Latin America experience a progressive decline in linear growth.

What is Known:

• Children with type 1 diabetes may experience impaired linear growth and lower BMI at disease onset, particularly in association with poor metabolic control.

What is New:

• This multicenter Latin American study showed that although BMI normalized after treatment initiation, children with type 1 diabetes exhibited a progressive decline in height z-scores over the first three years after diagnosis compared with healthy controls.