The objective of this study was to analyze the 24-h pH and multiple intraluminal impedance (pH-MII) monitoring results in pediatric patients with airway malacia, with the aim of comprehensively understanding the characteristics of gastroesophageal reflux (GER) in these patients and exploring their potential roles in the pathogenesis of airway malacia. This retrospective cohort study enrolled pediatric patients who underwent 24-h pH-MII monitoring and bronchoscopy at Maternal and Child Health Hospital of Hubei Province from January 2017 to October 2023. Among 64 pediatric patients with airway malacia, 24 (37.5%) patients met the diagnostic criteria for GERD. Compared to those without airway malacia, patients with airway malacia showed significantly higher acid reflux index (RI) (3.00% vs 1.60%, p = 0.021), acidic liquid reflux (8.50% vs 5.00%, p = 0.016), and pH reflux episodes (51.00 vs 26.00, p = 0.047). Age-stratified analysis showed that older children (≥1 year) exhibited higher acid reflux (36.0% vs 26.0%, p = 0.047), while infants (<1 year) exhibited elevated weakly acidic reflux (64.0% vs 53.0%, p = 0.013). Analysis of the receiver operating characteristic (ROC) curve for diagnosis identified sex, age, RI, and acid reflux as factors associated with airway malacia. Conclusion: PH-MII characterized age-dependent reflux profiles in airway malacia pediatrics. Acid reflux appears to play a pivotal pathogenic role in older children, whereas weakly acidic reflux is predominant in infants. These findings support age-tailored strategies: acid suppression for older children with high acid reflux and dietary modifications to reduce weak acidic exposure in infants.<Table Float="No" ID="Taba"> <tgroup cols="2"> <colspec align="left" colname="c1" colnum="1" /> <colspec align="left" colname="c2" colnum="2" /> <tbody> <row> <entry nameend="c2" namest="c1"> What is Known: • A large number of studies have confirmed that gastroesophageal reflux disease is one of the etiological factors of airway malacia in children. </entry> </row> <row> <entry nameend="c2" namest="c1"> What is New: • The reflux characteristics of children with airway malacia in different age groups are different, and the methods of anti-reflux treatment should also be different. </entry> </row> </tbody> </tgroup> </Table>

Acid and weakly acidic reflux characteristics in pediatric airway malacia by pH and multiple intraluminal impedance monitoring: a retrospective cohort study

期刊论文
发表日期：

2025年8月26日

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Yi Gan,
Ruxin Zhang,
Xiaoqin Zhou,
Guirong Wang,
Huiping Zhang,
Huiyu Qin,
JinShan Guo,
Jiantao Zhang,
Li Gu,
Di Zhang,
Fang Zeng,
Danna Tu,
Junhua Shu

摘要

The objective of this study was to analyze the 24-h pH and multiple intraluminal impedance (pH-MII) monitoring results in pediatric patients with airway malacia, with the aim of comprehensively understanding the characteristics of gastroesophageal reflux (GER) in these patients and exploring their potential roles in the pathogenesis of airway malacia. This retrospective cohort study enrolled pediatric patients who underwent 24-h pH-MII monitoring and bronchoscopy at Maternal and Child Health Hospital of Hubei Province from January 2017 to October 2023. Among 64 pediatric patients with airway malacia, 24 (37.5%) patients met the diagnostic criteria for GERD. Compared to those without airway malacia, patients with airway malacia showed significantly higher acid reflux index (RI) (3.00% vs 1.60%, p = 0.021), acidic liquid reflux (8.50% vs 5.00%, p = 0.016), and pH reflux episodes (51.00 vs 26.00, p = 0.047). Age-stratified analysis showed that older children (≥1 year) exhibited higher acid reflux (36.0% vs 26.0%, p = 0.047), while infants (<1 year) exhibited elevated weakly acidic reflux (64.0% vs 53.0%, p = 0.013). Analysis of the receiver operating characteristic (ROC) curve for diagnosis identified sex, age, RI, and acid reflux as factors associated with airway malacia. Conclusion: PH-MII characterized age-dependent reflux profiles in airway malacia pediatrics. Acid reflux appears to play a pivotal pathogenic role in older children, whereas weakly acidic reflux is predominant in infants. These findings support age-tailored strategies: acid suppression for older children with high acid reflux and dietary modifications to reduce weak acidic exposure in infants.

What is Known:

• A large number of studies have confirmed that gastroesophageal reflux disease is one of the etiological factors of airway malacia in children.

What is New:

• The reflux characteristics of children with airway malacia in different age groups are different, and the methods of anti-reflux treatment should also be different.