Plastic bronchitis (PB) is one of the pulmonary complications associated with Mycoplasma pneumoniae pneumonia (MPP). Early diagnosis of PB is challenging, and delayed removal of bronchial casts may lead to an increased risk of poor prognosis in MPP patients. This study aims to investigate the role of the volume ratio of pulmonary lesions, as evaluated by chest CT, in identifying PB in children with MPP. A total of 273 children diagnosed with MPP and treated with fiberoptic bronchoscopy (FB) were included in the study. The children were divided into two groups based on the presence or absence of PB. Clinical characteristics and lung volume data analyzed using 3D Slicer software were compared between the two groups. The PB group showed significantly higher levels of C-reactive protein (CRP), procalcitonin (PCT), D-dimer, lactate dehydrogenase (LDH), aspartate transaminase (AST), and alanine transaminase (ALT), as well as lower lymphocyte counts (P < 0.001). The proportion of pleural effusion, as assessed by chest CT, was also significantly higher in the PB group compared to the non-PB group (63.41%vs. 25.86%; P < 0.001). Regarding treatments, the PB group had a higher proportion of multiple FB therapies (85.37% vs. 16.81%), secondary antimicrobials use (46.34% vs. 10.43%), corticosteroid resistance (68.29% vs. 12.50%), and intravenous immunoglobulin (IVIG) treatment (29.27% vs .4.31%) compared to the non-PB group (P < 0.001). The volume ratio of pulmonary lesions was significantly higher in the PB group than in the non-PB group (P < 0.001). Using a threshold of more than 8.23%, the sensitivity and specificity for identifying PB were 95.12% and 77.16%, respectively, with an excellent AUC value (0.920, 95% CI 0.879–0.962). In all MPP patients, a positive linear relationship was observed between MP-DNA copy grade and the volume ratio of pulmonary lesions, with a high degree of correlation (rs = 0.88, P < 0.001).Conclusions: The volume ratio of pulmonary lesions may serve as a promising indicator for identifying PB in children with MPP.<Table Float="No" ID="Taba"> <tgroup cols="1"> <colspec align="left" colname="c1" colnum="1" /> <tbody> <row> <entry align="left" colname="c1"> What is Known: • Mycoplasma pneumoniae pneumonia (MPP) can lead to plastic bronchitis (PB). </entry> </row> <row> <entry align="left" colname="c1"> What is New: • The volume ratio of pulmonary lesions based on chest CT can predict the occurrence of MPP-associated PB. </entry> </row> </tbody> </tgroup> </Table>

Volume ratio of pulmonary lesions as a novel indicator for predicting the occurrence of plastic bronchitis in children with Mycoplasma pneumoniae pneumonia

期刊论文
发表日期：

2025年6月9日

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Yanqun Jiang,
Jianmei Tian,
Fangfang Cheng,
Xiaoxing Kong,
Ting Shi,
Yuanxi Bian,
Jiahui Wu

摘要

Plastic bronchitis (PB) is one of the pulmonary complications associated with Mycoplasma pneumoniae pneumonia (MPP). Early diagnosis of PB is challenging, and delayed removal of bronchial casts may lead to an increased risk of poor prognosis in MPP patients. This study aims to investigate the role of the volume ratio of pulmonary lesions, as evaluated by chest CT, in identifying PB in children with MPP. A total of 273 children diagnosed with MPP and treated with fiberoptic bronchoscopy (FB) were included in the study. The children were divided into two groups based on the presence or absence of PB. Clinical characteristics and lung volume data analyzed using 3D Slicer software were compared between the two groups. The PB group showed significantly higher levels of C-reactive protein (CRP), procalcitonin (PCT), D-dimer, lactate dehydrogenase (LDH), aspartate transaminase (AST), and alanine transaminase (ALT), as well as lower lymphocyte counts (P < 0.001). The proportion of pleural effusion, as assessed by chest CT, was also significantly higher in the PB group compared to the non-PB group (63.41%vs. 25.86%; P < 0.001). Regarding treatments, the PB group had a higher proportion of multiple FB therapies (85.37% vs. 16.81%), secondary antimicrobials use (46.34% vs. 10.43%), corticosteroid resistance (68.29% vs. 12.50%), and intravenous immunoglobulin (IVIG) treatment (29.27% vs .4.31%) compared to the non-PB group (P < 0.001). The volume ratio of pulmonary lesions was significantly higher in the PB group than in the non-PB group (P < 0.001). Using a threshold of more than 8.23%, the sensitivity and specificity for identifying PB were 95.12% and 77.16%, respectively, with an excellent AUC value (0.920, 95% CI 0.879–0.962). In all MPP patients, a positive linear relationship was observed between MP-DNA copy grade and the volume ratio of pulmonary lesions, with a high degree of correlation (r_s = 0.88, P < 0.001).

Conclusions: The volume ratio of pulmonary lesions may serve as a promising indicator for identifying PB in children with MPP.

What is Known:

• Mycoplasma pneumoniae pneumonia (MPP) can lead to plastic bronchitis (PB).

What is New:

• The volume ratio of pulmonary lesions based on chest CT can predict the occurrence of MPP-associated PB.