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<p>IgG antibodies against terminal galactose-α-1,3-galactose (anti-αGal antibodies) are naturally occurring in humans, but their origins remain poorly understood. These antibodies target various microorganisms including <i>Staphylococcus aureus</i>, a common nasal commensal and the major cause of skin abscesses. This study investigates the impact of <i>S. aureus</i> colonization and abscess events on plasma anti-αGal antibody levels. We measured plasma anti-αGal antibody levels using a quantitative immunoassay in: (i) 101 pairs of healthy individuals with and without nasal <i>S. aureus</i> colonization, (ii) 106 healthy individuals before and after abscess formation, and (iii) 43 patients with recurrent skin abscesses compared with 75 patient controls and 60 healthy controls. We observed a 35% reduction (95%CI: 7–54%) in anti-αGal antibody levels in nasal <i>S. aureus</i> carriers. Conversely, we found a 30% increase (95%CI: 4–66%) in individuals within 187 days post-skin abscess, and patients with recurrent skin abscesses exhibited 81% higher (95%CI: 14–190%) levels than patient controls, and 110% higher (95%CI: 39–230%) than healthy controls. This study suggests that skin abscesses lead to elevated plasma anti-αGal antibody levels and that these antibodies might convey or correlate with mucosal immunity to <i>S. aureus</i>.</p>

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Impact of Staphylococcus aureus colonization and skin abscesses on formation of human anti-αGal antibodies

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月13日

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  • Jens Magnus Bernth Jensen,
  • Khoa Manh Dinh,
  • Lotte Hindhede,
  • Lise Tornvig Erikstrup,
  • Annette Gudmann Hansen,
  • Kirstine Mejlstrup Hymøller,
  • Sisse Rye Ostrowski,
  • Ole B. V. Pedersen,
  • Stig Hill Christiansen,
  • Uffe B. Skov Sørensen,
  • Steffen Thiel,
  • Christian Erikstrup

摘要

IgG antibodies against terminal galactose-α-1,3-galactose (anti-αGal antibodies) are naturally occurring in humans, but their origins remain poorly understood. These antibodies target various microorganisms including Staphylococcus aureus, a common nasal commensal and the major cause of skin abscesses. This study investigates the impact of S. aureus colonization and abscess events on plasma anti-αGal antibody levels. We measured plasma anti-αGal antibody levels using a quantitative immunoassay in: (i) 101 pairs of healthy individuals with and without nasal S. aureus colonization, (ii) 106 healthy individuals before and after abscess formation, and (iii) 43 patients with recurrent skin abscesses compared with 75 patient controls and 60 healthy controls. We observed a 35% reduction (95%CI: 7–54%) in anti-αGal antibody levels in nasal S. aureus carriers. Conversely, we found a 30% increase (95%CI: 4–66%) in individuals within 187 days post-skin abscess, and patients with recurrent skin abscesses exhibited 81% higher (95%CI: 14–190%) levels than patient controls, and 110% higher (95%CI: 39–230%) than healthy controls. This study suggests that skin abscesses lead to elevated plasma anti-αGal antibody levels and that these antibodies might convey or correlate with mucosal immunity to S. aureus.