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<p>Fos immunohistochemistry was used to identify neurons in taste-related brain areas throughout the B6 mouse brain activated by intra-oral (IO) infusion of 3.0 mM quinine hydrochloride (Q), 1.0&#xa0;M sucrose (S) or filtered water (W). IO infusion of Q and S elicited more Fos-immunoreactive (Fos-IR) neurons than W in the central medial (CM) and dorsomedial (DM) subareas of the parabrachial nucleus (PBN) and the central medial (CeM) amygdala (ps &lt; 0.05). Infusion of Q led to more Fos expression than W in the central lateral (CL) PBN and the parvocellular reticular formation (PCRT; ps &lt; 0.05). The only area where IO infusion of Q and S elicited a different number of Fos-IR neurons was the PCRT which responded more to Q (<i>p</i> &lt; 0.05). Cluster analysis of the number of Fos-IR neurons in all 29 taste-related nuclei and subareas examined revealed that populations of neurons distributed among these brain regions respond best to Q, S or both Q and S. Specifically, the Q-best cluster included more posterior structures like the nucleus of the solitary tract, RT and part of the PBN. The S-best cluster included more anterior structures like the bed nucleus of the stria terminalis, nucleus accumbens and orbitofrontal cortex. And, the cluster of areas that responded better to Q and S than W included the amygdala, gustatory and piriform cortices and a few PBN subareas. Therefore, the data suggest that collections of neurons among taste-responsive brain areas are important for distinguishing Q and S from water as well as identifying the specific tastant.</p>

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Mapping Fos-immunoreactive neurons activated by intra-oral infusion of quinine, sucrose or water throughout the brain of B6 mice

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月21日

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  • Michael S. King,
  • Lianyi Lu,
  • Max L. Fletcher,
  • John D. Boughter Jr

摘要

Fos immunohistochemistry was used to identify neurons in taste-related brain areas throughout the B6 mouse brain activated by intra-oral (IO) infusion of 3.0 mM quinine hydrochloride (Q), 1.0 M sucrose (S) or filtered water (W). IO infusion of Q and S elicited more Fos-immunoreactive (Fos-IR) neurons than W in the central medial (CM) and dorsomedial (DM) subareas of the parabrachial nucleus (PBN) and the central medial (CeM) amygdala (ps < 0.05). Infusion of Q led to more Fos expression than W in the central lateral (CL) PBN and the parvocellular reticular formation (PCRT; ps < 0.05). The only area where IO infusion of Q and S elicited a different number of Fos-IR neurons was the PCRT which responded more to Q (p < 0.05). Cluster analysis of the number of Fos-IR neurons in all 29 taste-related nuclei and subareas examined revealed that populations of neurons distributed among these brain regions respond best to Q, S or both Q and S. Specifically, the Q-best cluster included more posterior structures like the nucleus of the solitary tract, RT and part of the PBN. The S-best cluster included more anterior structures like the bed nucleus of the stria terminalis, nucleus accumbens and orbitofrontal cortex. And, the cluster of areas that responded better to Q and S than W included the amygdala, gustatory and piriform cortices and a few PBN subareas. Therefore, the data suggest that collections of neurons among taste-responsive brain areas are important for distinguishing Q and S from water as well as identifying the specific tastant.