Scholarlink

<p><i>BEND2</i>-rearranged neoplasms represent a newly emerging group of tumors with variable morphology, involving multiple tissue types and anatomical sites such as the central nervous system, bone, soft tissue, and salivary glands. Here, we describe a novel <i>CHD9::BEND2</i> fusion in a low-grade spindle cell mesenchymal tumor arising in the sinonasal tract of a 5-year-old girl. Histologically, the tumor exhibited ovoid to spindle-shaped cells with moderate atypia, numerous thin-walled vessels, and focal necrosis. Immunohistochemistry did not indicate a specific line of differentiation, showing focal SATB2 positivity and a low proliferative index. The <i>CHD9::BEND2</i> fusion was identified by whole transcriptome sequencing and confirmed by RT-PCR, Sanger sequencing, and break-apart FISH. This case broadens the clinicopathological and molecular spectrum of <i>BEND2</i>-associated tumors, suggesting a potential oncogenic role of <i>CHD9::BEND2</i> in pediatric mesenchymal neoplasia.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A pediatric low-grade sinonasal mesenchymal tumor harboring a novel CHD9::BEND2 fusion

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月20日

查看全文
  • Huiting Wei,
  • Dawei Liu,
  • Yanan Li,
  • Huijuan Shi,
  • Sheng Xiao,
  • Anjia Han

摘要

BEND2-rearranged neoplasms represent a newly emerging group of tumors with variable morphology, involving multiple tissue types and anatomical sites such as the central nervous system, bone, soft tissue, and salivary glands. Here, we describe a novel CHD9::BEND2 fusion in a low-grade spindle cell mesenchymal tumor arising in the sinonasal tract of a 5-year-old girl. Histologically, the tumor exhibited ovoid to spindle-shaped cells with moderate atypia, numerous thin-walled vessels, and focal necrosis. Immunohistochemistry did not indicate a specific line of differentiation, showing focal SATB2 positivity and a low proliferative index. The CHD9::BEND2 fusion was identified by whole transcriptome sequencing and confirmed by RT-PCR, Sanger sequencing, and break-apart FISH. This case broadens the clinicopathological and molecular spectrum of BEND2-associated tumors, suggesting a potential oncogenic role of CHD9::BEND2 in pediatric mesenchymal neoplasia.