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Aims <p>To investigate effect of cyanoacrylate-based glue on postoperative leak and bleeding after pancreatectomy and sleeve gastrectomy.</p> Methods <p>A PRISMA-compliant systematic review and meta-analysis using random effects modelling was performed including studies investigating effect of cyanoacrylate-based glue on postoperative leak and bleeding in patients undergoing pancreatectomy and sleeve gastrectomy. Proportion meta-analysis and comparison meta-analysis were modelled to evaluate the outcomes.</p> Results <p>Analysis of 1800 patients from nine studies showed no difference in the risk of postoperative leak between the cyanoacrylate-based glue and no glue groups in all pancreatic resections (OR: 1.26, <i>p</i> = 0.700), in pancreaticoduodenectomy with total duct occlusion (OR: 3.21, <i>p</i> = 0.360), in pancreaticoduodenectomy with pancreaticojejunostomy (OR: 0.42, <i>p</i> = 0.550), in distal pancreatectomy (OR: 1.50, <i>p</i> = 0.330), and in sleeve gastrectomy (OR: 0.14, <i>p</i> = 0.07). Moreover, there was no difference in the risk of postoperative bleeding between the cyanoacrylate-based glue and no glue groups in all pancreatic resections (OR: 1.44, <i>p</i> = 0.460), in pancreaticoduodenectomy with total duct occlusion (OR: 0.35, <i>p</i> = 0.520), in pancreaticoduodenectomy with pancreaticojejunostomy (OR: 2.75, <i>p</i> = 0.080), in distal pancreatectomy (OR: 0.72, <i>p</i> = 0.670), and in sleeve gastrectomy (OR: 0.37, <i>p</i> = 0.14). Cyanoacrylate-based glue did not reduce the risk of grade A (OR: 1.16, <i>p</i> = 0.82), grade B (OR: 1.29, <i>p</i> = 0.460), and grade C (OR: 0.36, 3.16, <i>p</i> = 0.360) postoperative pancreatic fistula.</p> Conclusions <p>Level 2 evidence with moderate certainty suggests that cyanoacrylate-based glue does not reduce the risk of postoperative leak and bleeding after pancreatectomy and sleeve gastrectomy. More studies with larger sample sizes are required to exclude type 2 error.</p>

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Effect of cyanoacrylate-based glue on postoperative leak and bleeding after pancreatectomy and sleeve gastrectomy: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月30日

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  • Shahab Hajibandeh,
  • Arshad Siddiqui,
  • Elorm Daketsey,
  • Nisha Mallya,
  • Sharanga Thuvaraganathan,
  • Rhys Thomas,
  • Ayman Ashabi,
  • Shahin Hajibandeh,
  • Nicholas G. Mowbray,
  • Matthew Mortimer,
  • Guy Shingler,
  • Bilal Al-Sarireh,
  • Amir Kambal

摘要

Aims

To investigate effect of cyanoacrylate-based glue on postoperative leak and bleeding after pancreatectomy and sleeve gastrectomy.

Methods

A PRISMA-compliant systematic review and meta-analysis using random effects modelling was performed including studies investigating effect of cyanoacrylate-based glue on postoperative leak and bleeding in patients undergoing pancreatectomy and sleeve gastrectomy. Proportion meta-analysis and comparison meta-analysis were modelled to evaluate the outcomes.

Results

Analysis of 1800 patients from nine studies showed no difference in the risk of postoperative leak between the cyanoacrylate-based glue and no glue groups in all pancreatic resections (OR: 1.26, p = 0.700), in pancreaticoduodenectomy with total duct occlusion (OR: 3.21, p = 0.360), in pancreaticoduodenectomy with pancreaticojejunostomy (OR: 0.42, p = 0.550), in distal pancreatectomy (OR: 1.50, p = 0.330), and in sleeve gastrectomy (OR: 0.14, p = 0.07). Moreover, there was no difference in the risk of postoperative bleeding between the cyanoacrylate-based glue and no glue groups in all pancreatic resections (OR: 1.44, p = 0.460), in pancreaticoduodenectomy with total duct occlusion (OR: 0.35, p = 0.520), in pancreaticoduodenectomy with pancreaticojejunostomy (OR: 2.75, p = 0.080), in distal pancreatectomy (OR: 0.72, p = 0.670), and in sleeve gastrectomy (OR: 0.37, p = 0.14). Cyanoacrylate-based glue did not reduce the risk of grade A (OR: 1.16, p = 0.82), grade B (OR: 1.29, p = 0.460), and grade C (OR: 0.36, 3.16, p = 0.360) postoperative pancreatic fistula.

Conclusions

Level 2 evidence with moderate certainty suggests that cyanoacrylate-based glue does not reduce the risk of postoperative leak and bleeding after pancreatectomy and sleeve gastrectomy. More studies with larger sample sizes are required to exclude type 2 error.