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Introduction <p>Pancreatoduodenectomy (PD) is a complex procedure associated with up to 20–30% morbidity and 1–2% mortality. In the present study, we aimed to evaluate the outcomes of PD in patients with cirrhotic liver and assessed predictors of perioperative morbidity and mortality.</p> Materials and methods <p>This is a retrospective study from a prospectively maintained database. Amongst the patients who underwent PD between January 2013 till June 2024, only patients who had underlying cirrhotic liver were included in the study.</p> Results <p>A total of 24 patients were included. On binary logistic regression history of pancreatitis in the preoperative period (OD-25.8), stent block (OD-64.9), cholangitis (OD-273), and preoperative platelets less than 1.37(OD-40), preoperative INR more than 1.31(OD-40) and platelets count on POD1 less than 1.23 lakhs (OD-40) were associated with mortality.</p> Conclusion <p>Patients with clinically significant portal hypertension with thrombocytopenia and a deranged coagulation profile are associated with a high risk of mortality.</p>

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Outcomes of pancreatoduodenectomy in underlying liver cirrhosis: a single institution experience and literature review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月8日

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  • Kunal Nandy,
  • Prem Kamal,
  • Amit Chopde,
  • Vikas Ostwal,
  • Anant Ramaswamy,
  • Akash Pawar,
  • Vikram Chaudhari,
  • Shailesh V Shrikhande,
  • Manish S Bhandare

摘要

Introduction

Pancreatoduodenectomy (PD) is a complex procedure associated with up to 20–30% morbidity and 1–2% mortality. In the present study, we aimed to evaluate the outcomes of PD in patients with cirrhotic liver and assessed predictors of perioperative morbidity and mortality.

Materials and methods

This is a retrospective study from a prospectively maintained database. Amongst the patients who underwent PD between January 2013 till June 2024, only patients who had underlying cirrhotic liver were included in the study.

Results

A total of 24 patients were included. On binary logistic regression history of pancreatitis in the preoperative period (OD-25.8), stent block (OD-64.9), cholangitis (OD-273), and preoperative platelets less than 1.37(OD-40), preoperative INR more than 1.31(OD-40) and platelets count on POD1 less than 1.23 lakhs (OD-40) were associated with mortality.

Conclusion

Patients with clinically significant portal hypertension with thrombocytopenia and a deranged coagulation profile are associated with a high risk of mortality.